Caspase function and the immune system

Sarita Sehra, Alexander Dent

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Caspases are key effector components of apoptosis, the process of programmed cell death. However, a large body of recent work has shown that caspase activity is necessary for several nonapoptotic cellular functions, such as proliferation, differentiation, survival, and the regulation of cytokine expression. In this review, we concentrate on the nonapoptotic functions of caspases and, in particular, on nonapoptotic roles of caspases in the immune system. Because of the involvement of caspases in promoting cell death, as well as cell proliferation and other nonapoptotic functions, studies involving the inhibition of caspases in vivo must be interpreted with caution.

Original languageEnglish
Pages (from-to)133-148
Number of pages16
JournalCritical Reviews in Immunology
Volume26
Issue number2
StatePublished - 2006

Fingerprint

Caspases
Immune System
Cell Death
Effector Caspases
Cell Proliferation
Apoptosis
Cytokines

Keywords

  • Apoptosis
  • Caspases
  • Proliferation
  • T-cell development
  • Th2-cell differentiation
  • Z-VAD

ASJC Scopus subject areas

  • Immunology

Cite this

Caspase function and the immune system. / Sehra, Sarita; Dent, Alexander.

In: Critical Reviews in Immunology, Vol. 26, No. 2, 2006, p. 133-148.

Research output: Contribution to journalArticle

Sehra, Sarita ; Dent, Alexander. / Caspase function and the immune system. In: Critical Reviews in Immunology. 2006 ; Vol. 26, No. 2. pp. 133-148.
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