Kaspazy i apoptoza: umrzyj i pozwól zyć.

Translated title of the contribution: Caspases and apoptosis: die and let live

Grzegorz Nalepa, Ewa Zukowska-Szczechowska

Research output: Contribution to journalReview article

14 Scopus citations

Abstract

Apoptosis (genetically programmed cell death) plays a key role in human physiology and pathogenesis of various diseases, including cancer. A suicide of cell can be initiated by many different factors, but activation of caspases, which are a special class of proteolytic enzymes, is always involved in this process. Activation of caspases may be achieved by several molecular pathways: the best known stimuli triggering caspase cascade are stimulation of Fas or TNF receptors, release of cytochrome c from the cellular mitochondria and exposure to granzymes, which are secreted by cytotoxic T cells. Activated caspases digest many cellular proteins responsible for cell cycle regulation (e.g. RB, MDM2), DNA damage recognition and repair (e.g. DNA-PK, P53, PARP), and regulation of the cellular structure (e.g. actin and lamins). All these functional and structural protein modifications lead directly to apoptosis. Further research on the mechanisms controlling caspase activity and the modes of action will provide better insight into pathogenesis of cancer and other disorders. It may be even the first step to design new and more efficient methods of conventional tumor treatment or gene therapy.

Translated title of the contributionCaspases and apoptosis: die and let live
Original languagePolish
Pages (from-to)100-106
Number of pages7
JournalWiadomości lekarskie (Warsaw, Poland : 1960)
Volume55
Issue number1-2
StatePublished - 2002

ASJC Scopus subject areas

  • Medicine(all)

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    Nalepa, G., & Zukowska-Szczechowska, E. (2002). Kaspazy i apoptoza: umrzyj i pozwól zyć. Wiadomości lekarskie (Warsaw, Poland : 1960), 55(1-2), 100-106.