Kaspazy i apoptoza: umrzyj i pozwól zyć.

Translated title of the contribution: Caspases and apoptosis: die and let live

Grzegorz Nalepa, Ewa Zukowska-Szczechowska

Research output: Contribution to journalReview article

14 Citations (Scopus)

Abstract

Apoptosis (genetically programmed cell death) plays a key role in human physiology and pathogenesis of various diseases, including cancer. A suicide of cell can be initiated by many different factors, but activation of caspases, which are a special class of proteolytic enzymes, is always involved in this process. Activation of caspases may be achieved by several molecular pathways: the best known stimuli triggering caspase cascade are stimulation of Fas or TNF receptors, release of cytochrome c from the cellular mitochondria and exposure to granzymes, which are secreted by cytotoxic T cells. Activated caspases digest many cellular proteins responsible for cell cycle regulation (e.g. RB, MDM2), DNA damage recognition and repair (e.g. DNA-PK, P53, PARP), and regulation of the cellular structure (e.g. actin and lamins). All these functional and structural protein modifications lead directly to apoptosis. Further research on the mechanisms controlling caspase activity and the modes of action will provide better insight into pathogenesis of cancer and other disorders. It may be even the first step to design new and more efficient methods of conventional tumor treatment or gene therapy.

Original languagePolish
Pages (from-to)100-106
Number of pages7
JournalWiadomosci Lekarskie
Volume55
Issue number1-2
StatePublished - 2002
Externally publishedYes

Fingerprint

Cell death
Caspases
Apoptosis
Proteins
DNA
Chemical activation
Gene therapy
Mitochondria
T-cells
Physiology
Tumors
Lamins
CD95 Antigens
Repair
Granzymes
Neoplasms
Cell Cycle Proteins
Cells
Tumor Necrosis Factor Receptors
Cellular Structures

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Nalepa, G., & Zukowska-Szczechowska, E. (2002). Kaspazy i apoptoza: umrzyj i pozwól zyć. Wiadomosci Lekarskie, 55(1-2), 100-106.

Kaspazy i apoptoza : umrzyj i pozwól zyć. / Nalepa, Grzegorz; Zukowska-Szczechowska, Ewa.

In: Wiadomosci Lekarskie, Vol. 55, No. 1-2, 2002, p. 100-106.

Research output: Contribution to journalReview article

Nalepa, G & Zukowska-Szczechowska, E 2002, 'Kaspazy i apoptoza: umrzyj i pozwól zyć.', Wiadomosci Lekarskie, vol. 55, no. 1-2, pp. 100-106.
Nalepa G, Zukowska-Szczechowska E. Kaspazy i apoptoza: umrzyj i pozwól zyć. Wiadomosci Lekarskie. 2002;55(1-2):100-106.
Nalepa, Grzegorz ; Zukowska-Szczechowska, Ewa. / Kaspazy i apoptoza : umrzyj i pozwól zyć. In: Wiadomosci Lekarskie. 2002 ; Vol. 55, No. 1-2. pp. 100-106.
@article{b4b104c239a74c6baaa28f14fcb63b8a,
title = "Kaspazy i apoptoza: umrzyj i pozw{\'o}l zyć.",
abstract = "Apoptosis (genetically programmed cell death) plays a key role in human physiology and pathogenesis of various diseases, including cancer. A suicide of cell can be initiated by many different factors, but activation of caspases, which are a special class of proteolytic enzymes, is always involved in this process. Activation of caspases may be achieved by several molecular pathways: the best known stimuli triggering caspase cascade are stimulation of Fas or TNF receptors, release of cytochrome c from the cellular mitochondria and exposure to granzymes, which are secreted by cytotoxic T cells. Activated caspases digest many cellular proteins responsible for cell cycle regulation (e.g. RB, MDM2), DNA damage recognition and repair (e.g. DNA-PK, P53, PARP), and regulation of the cellular structure (e.g. actin and lamins). All these functional and structural protein modifications lead directly to apoptosis. Further research on the mechanisms controlling caspase activity and the modes of action will provide better insight into pathogenesis of cancer and other disorders. It may be even the first step to design new and more efficient methods of conventional tumor treatment or gene therapy.",
author = "Grzegorz Nalepa and Ewa Zukowska-Szczechowska",
year = "2002",
language = "Polish",
volume = "55",
pages = "100--106",
journal = "Wiadomosci Lekarskie",
issn = "0043-5147",
publisher = "Fundacja Lekarzy Polskich-Pro-Medica",
number = "1-2",

}

TY - JOUR

T1 - Kaspazy i apoptoza

T2 - umrzyj i pozwól zyć.

AU - Nalepa, Grzegorz

AU - Zukowska-Szczechowska, Ewa

PY - 2002

Y1 - 2002

N2 - Apoptosis (genetically programmed cell death) plays a key role in human physiology and pathogenesis of various diseases, including cancer. A suicide of cell can be initiated by many different factors, but activation of caspases, which are a special class of proteolytic enzymes, is always involved in this process. Activation of caspases may be achieved by several molecular pathways: the best known stimuli triggering caspase cascade are stimulation of Fas or TNF receptors, release of cytochrome c from the cellular mitochondria and exposure to granzymes, which are secreted by cytotoxic T cells. Activated caspases digest many cellular proteins responsible for cell cycle regulation (e.g. RB, MDM2), DNA damage recognition and repair (e.g. DNA-PK, P53, PARP), and regulation of the cellular structure (e.g. actin and lamins). All these functional and structural protein modifications lead directly to apoptosis. Further research on the mechanisms controlling caspase activity and the modes of action will provide better insight into pathogenesis of cancer and other disorders. It may be even the first step to design new and more efficient methods of conventional tumor treatment or gene therapy.

AB - Apoptosis (genetically programmed cell death) plays a key role in human physiology and pathogenesis of various diseases, including cancer. A suicide of cell can be initiated by many different factors, but activation of caspases, which are a special class of proteolytic enzymes, is always involved in this process. Activation of caspases may be achieved by several molecular pathways: the best known stimuli triggering caspase cascade are stimulation of Fas or TNF receptors, release of cytochrome c from the cellular mitochondria and exposure to granzymes, which are secreted by cytotoxic T cells. Activated caspases digest many cellular proteins responsible for cell cycle regulation (e.g. RB, MDM2), DNA damage recognition and repair (e.g. DNA-PK, P53, PARP), and regulation of the cellular structure (e.g. actin and lamins). All these functional and structural protein modifications lead directly to apoptosis. Further research on the mechanisms controlling caspase activity and the modes of action will provide better insight into pathogenesis of cancer and other disorders. It may be even the first step to design new and more efficient methods of conventional tumor treatment or gene therapy.

UR - http://www.scopus.com/inward/record.url?scp=2242435231&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2242435231&partnerID=8YFLogxK

M3 - Review article

C2 - 12043304

AN - SCOPUS:2242435231

VL - 55

SP - 100

EP - 106

JO - Wiadomosci Lekarskie

JF - Wiadomosci Lekarskie

SN - 0043-5147

IS - 1-2

ER -