Ca2+ Regulation and Endothelial Vascular Function

Wolfgang F. Graier, Michael Sturek, Walter R. Kukovetz

Research output: Contribution to journalArticlepeer-review

54 Scopus citations


The vascular endothelium is now recognized as an important organ in the non-neural regulation of vascular tone. In particular, it is now well established that endothelial cells release various paracrine factors that relax as well as contract vascular smooth muscle cells. The relaxing factors include endothelium-derived relaxing factor (EDRF), which has been demonstrated to be nitric oxide or a nitric oxide-containing compound, prostacyclin (PGI2) and endothelium-derived hyperpolarizing factor (EDHF). The chemical properties and nature of EDHF are still unknown. Endothelial cells also release vasoconstrictor peptides, the endothelins, which increase smooth muscle Ca 2+ concentration, resulting in potent vasoconstriction. Since the formation of all these endothelium-derived factors is due to changes in endothelial free Ca2+, the main purpose of the present review is to summarize current knowledge of the underlying molecular mechanisms involved in agonist-induced Ca2+ regulation and the mechanisms by which endothelial Ca 2+ concentrations regulate the formation of endothelium-derived vasoactive factors.

Original languageEnglish (US)
Pages (from-to)223-236
Number of pages14
Issue number4
StatePublished - Jan 1 1994
Externally publishedYes


  • endothelial Ca
  • endothelin
  • endothelium-derived hyperpolarizing factor
  • endothelium-derived nitric oxide
  • endothelium-derived relaxing factors
  • prostacyclin

ASJC Scopus subject areas

  • Physiology
  • Cell Biology

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