Catalytic domains of matrix metalloproteinases: A molecular biology approach to drug discovery

Qi Zhuang Ye, Donald Hupe, Linda Johnson

Research output: Contribution to journalReview article

15 Scopus citations

Abstract

Molecular biology has provided a range of tools for drug research. The work in the matrix metalloproteinase (MMP) catalytic domain area demonstrated one of the molecular biology approaches to drug discovery. Matrix metalloproteinases are a family of zinc containing proteinases involved in connective tissue remodeling and implicated in diseases such as arthritis, cancer metastasis, and periodontal diseases. Several catalytic domains of human MMPs have been expressed in E. coli and used for random inhibitor screening, protein/inhibitor complex structural determinations, and protein structure-function studies, promising a new generation of MMP inhibitors with high affinity, high selectivity, and high bioavailabitity as therapeutical agents.

Original languageEnglish (US)
Pages (from-to)407-418
Number of pages12
JournalCurrent Medicinal Chemistry
Volume3
Issue number6
StatePublished - Dec 1 1996
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

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