Amyloid A protein (AA), the chief constituent of reactive amyloid deposits, is derived from serum amyloid A (SAA) and most commonly corresponds to the amino‐terminal 76 residues (AA76). Digestion of recombinant human SAAl with a lysosomal thiol protease, cathepsin B. and analysis of the products by SDS‐PAGE and amino‐terminal sequencing revealed that AA76 was generated as a minor and transient degradation product. Digestion with neutrophil eiastase generated intermediates different from AA76. This finding suggests that cathepsin B may play an important role in amyloid fibrilogenesis by converting SAA to AA.
|Original language||English (US)|
|Number of pages||4|
|Journal||Scandinavian Journal of Immunology|
|State||Published - Jan 1995|
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