Cathepsin B Generates the Most Common Form of Amyloid A (76 Residues) as a Degradation Product from Serum Amyloid A

T. YAMADA, J. J. LIEPNIEKS, B. KLUVE‐BECKERMAN, M. D. BENSON

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Abstract

Amyloid A protein (AA), the chief constituent of reactive amyloid deposits, is derived from serum amyloid A (SAA) and most commonly corresponds to the amino‐terminal 76 residues (AA76). Digestion of recombinant human SAAl with a lysosomal thiol protease, cathepsin B. and analysis of the products by SDS‐PAGE and amino‐terminal sequencing revealed that AA76 was generated as a minor and transient degradation product. Digestion with neutrophil eiastase generated intermediates different from AA76. This finding suggests that cathepsin B may play an important role in amyloid fibrilogenesis by converting SAA to AA.

Original languageEnglish (US)
Pages (from-to)94-97
Number of pages4
JournalScandinavian Journal of Immunology
Volume41
Issue number1
DOIs
StatePublished - Jan 1995

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ASJC Scopus subject areas

  • Immunology

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