Cathepsin K expression in a wide spectrum of perivascular epithelioid cell neoplasms (PEComas): A clinicopathological study emphasizing extrarenal PEComas

Qiu Rao, Liang Cheng, Qiu yuan Xia, Biao Liu, Li Li, Qun li Shi, Shan shan Shi, Bo Yu, Ru song Zhang, Heng hui Ma, Zhen feng Lu, Pin Tu, Xiao jun Zhou

Research output: Contribution to journalArticle

54 Scopus citations

Abstract

Aims: Recent studies have demonstrated that cathepsin K seems to be a powerful marker in identifying renal perivascular epithelioid cell neoplasms (PEComas). However, the expression in extrarenal PEComas has not been well characterized due to their rare incidence. Our aim was to investigate the expression of cathepsin K in a wide spectrum of extrar-enal PEComas and evaluate its potential diagnostic usefulness in comparison with other commonly used markers. Methods and results: Twenty-three cases of PEComa (liver, n = 9; lung, n = 1; broad ligament of uterus, n = 1; vertex subcutaneous soft tissue, n = 1; abdominal wall, n = 1; and kidney, n = 10) were selected for study. All displayed a high percentage of cells with moderately to strongly positive reactions for cathepsin K (mean 91%; range 80-100%). HMB45, Melan-A and smooth muscle actin (SMA) were expressed in 78, 87 and 87% of cases, respectively, with various percentages of positive cells (mean, 34, 40 and 38%; range 0-80, 0-90 and 0-90%). Transcription factor E3 (TFE3) was expressed strongly in only three cases; none exhibited evidence of TFE3 gene fusion or amplification. Conclusions: Cathepsin K appears to be more powerful than other commonly used markers in diagnosing a wide spectrum of PEComas and distinguishing them from the majority of human cancers.

Original languageEnglish (US)
Pages (from-to)642-650
Number of pages9
JournalHistopathology
Volume62
Issue number4
DOIs
StatePublished - Mar 2013

Keywords

  • Angiomyolipoma
  • Cathepsin K
  • Immunohistochemistry
  • PEComa
  • Tuberous sclerosis

ASJC Scopus subject areas

  • Histology
  • Pathology and Forensic Medicine

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  • Cite this

    Rao, Q., Cheng, L., Xia, Q. Y., Liu, B., Li, L., Shi, Q. L., Shi, S. S., Yu, B., Zhang, R. S., Ma, H. H., Lu, Z. F., Tu, P., & Zhou, X. J. (2013). Cathepsin K expression in a wide spectrum of perivascular epithelioid cell neoplasms (PEComas): A clinicopathological study emphasizing extrarenal PEComas. Histopathology, 62(4), 642-650. https://doi.org/10.1111/his.12059