Cathepsin K expression in a wide spectrum of perivascular epithelioid cell neoplasms (PEComas)

A clinicopathological study emphasizing extrarenal PEComas

Qiu Rao, Liang Cheng, Qiu yuan Xia, Biao Liu, Li Li, Qun li Shi, Shan shan Shi, Bo Yu, Ru song Zhang, Heng hui Ma, Zhen feng Lu, Pin Tu, Xiao jun Zhou

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Aims: Recent studies have demonstrated that cathepsin K seems to be a powerful marker in identifying renal perivascular epithelioid cell neoplasms (PEComas). However, the expression in extrarenal PEComas has not been well characterized due to their rare incidence. Our aim was to investigate the expression of cathepsin K in a wide spectrum of extrar-enal PEComas and evaluate its potential diagnostic usefulness in comparison with other commonly used markers. Methods and results: Twenty-three cases of PEComa (liver, n = 9; lung, n = 1; broad ligament of uterus, n = 1; vertex subcutaneous soft tissue, n = 1; abdominal wall, n = 1; and kidney, n = 10) were selected for study. All displayed a high percentage of cells with moderately to strongly positive reactions for cathepsin K (mean 91%; range 80-100%). HMB45, Melan-A and smooth muscle actin (SMA) were expressed in 78, 87 and 87% of cases, respectively, with various percentages of positive cells (mean, 34, 40 and 38%; range 0-80, 0-90 and 0-90%). Transcription factor E3 (TFE3) was expressed strongly in only three cases; none exhibited evidence of TFE3 gene fusion or amplification. Conclusions: Cathepsin K appears to be more powerful than other commonly used markers in diagnosing a wide spectrum of PEComas and distinguishing them from the majority of human cancers.

Original languageEnglish
Pages (from-to)642-650
Number of pages9
JournalHistopathology
Volume62
Issue number4
DOIs
StatePublished - Mar 2013

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Perivascular Epithelioid Cell Neoplasms
Cathepsin K
Transcription Factors
Broad Ligament
MART-1 Antigen
Gene Amplification
Kidney Neoplasms
Gene Fusion
Subcutaneous Tissue
Abdominal Wall
Uterus
Smooth Muscle
Actins
Kidney
Lung
Liver
Incidence

Keywords

  • Angiomyolipoma
  • Cathepsin K
  • Immunohistochemistry
  • PEComa
  • Tuberous sclerosis

ASJC Scopus subject areas

  • Histology
  • Pathology and Forensic Medicine

Cite this

Cathepsin K expression in a wide spectrum of perivascular epithelioid cell neoplasms (PEComas) : A clinicopathological study emphasizing extrarenal PEComas. / Rao, Qiu; Cheng, Liang; Xia, Qiu yuan; Liu, Biao; Li, Li; Shi, Qun li; Shi, Shan shan; Yu, Bo; Zhang, Ru song; Ma, Heng hui; Lu, Zhen feng; Tu, Pin; Zhou, Xiao jun.

In: Histopathology, Vol. 62, No. 4, 03.2013, p. 642-650.

Research output: Contribution to journalArticle

Rao, Q, Cheng, L, Xia, QY, Liu, B, Li, L, Shi, QL, Shi, SS, Yu, B, Zhang, RS, Ma, HH, Lu, ZF, Tu, P & Zhou, XJ 2013, 'Cathepsin K expression in a wide spectrum of perivascular epithelioid cell neoplasms (PEComas): A clinicopathological study emphasizing extrarenal PEComas', Histopathology, vol. 62, no. 4, pp. 642-650. https://doi.org/10.1111/his.12059
Rao, Qiu ; Cheng, Liang ; Xia, Qiu yuan ; Liu, Biao ; Li, Li ; Shi, Qun li ; Shi, Shan shan ; Yu, Bo ; Zhang, Ru song ; Ma, Heng hui ; Lu, Zhen feng ; Tu, Pin ; Zhou, Xiao jun. / Cathepsin K expression in a wide spectrum of perivascular epithelioid cell neoplasms (PEComas) : A clinicopathological study emphasizing extrarenal PEComas. In: Histopathology. 2013 ; Vol. 62, No. 4. pp. 642-650.
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abstract = "Aims: Recent studies have demonstrated that cathepsin K seems to be a powerful marker in identifying renal perivascular epithelioid cell neoplasms (PEComas). However, the expression in extrarenal PEComas has not been well characterized due to their rare incidence. Our aim was to investigate the expression of cathepsin K in a wide spectrum of extrar-enal PEComas and evaluate its potential diagnostic usefulness in comparison with other commonly used markers. Methods and results: Twenty-three cases of PEComa (liver, n = 9; lung, n = 1; broad ligament of uterus, n = 1; vertex subcutaneous soft tissue, n = 1; abdominal wall, n = 1; and kidney, n = 10) were selected for study. All displayed a high percentage of cells with moderately to strongly positive reactions for cathepsin K (mean 91{\%}; range 80-100{\%}). HMB45, Melan-A and smooth muscle actin (SMA) were expressed in 78, 87 and 87{\%} of cases, respectively, with various percentages of positive cells (mean, 34, 40 and 38{\%}; range 0-80, 0-90 and 0-90{\%}). Transcription factor E3 (TFE3) was expressed strongly in only three cases; none exhibited evidence of TFE3 gene fusion or amplification. Conclusions: Cathepsin K appears to be more powerful than other commonly used markers in diagnosing a wide spectrum of PEComas and distinguishing them from the majority of human cancers.",
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AU - Xia, Qiu yuan

AU - Liu, Biao

AU - Li, Li

AU - Shi, Qun li

AU - Shi, Shan shan

AU - Yu, Bo

AU - Zhang, Ru song

AU - Ma, Heng hui

AU - Lu, Zhen feng

AU - Tu, Pin

AU - Zhou, Xiao jun

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