Catheter Ablation of Ventricular Fibrillation in Rabbit Ventricles Treated with β-Blockers

Hui Nam Pak, Yong Seog Oh, Yen Bin Liu, Tsu Juey Wu, Hrayr S. Karagueuzian, Shien-Fong Lin, Peng-Sheng Chen

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Background-A therapeutic implication of the focal-source hypothesis of ventricular fibrillation (VF) is that VF can be terminated by focal ablation. We hypothesize that β-adrenergic receptor blockade converts multiple-wavelet VF to focal-source VF and that this focal source is located near the papillary muscle (PM). Methods and Results-We used optical mapping techniques to study the effects of propranolol (0.3 mg/L) on VF dynamics in Langendorff-perfused rabbit hearts. The left ventricular (LV) anterior wall was mapped and optical action potential duration restitution (APDR) was determined at 25 epicardial sites. We performed ablation during VF of the left anterior PM in hearts with (N=6) or without (N=6) cytochalasin infusion, the LV lateral epicardium (Epi group, N=3), and the LV endocardium (Endo group, N=3). The PM was also ablated in 3 hearts without propranolol (control group). Propranolol converted multiple-wavelet VF to slow VF with reentry localized to the PM. Propranolol decreased the maximal slope of the APDR curve (P

Original languageEnglish (US)
Pages (from-to)3149-3156
Number of pages8
JournalCirculation
Volume108
Issue number25
DOIs
StatePublished - Dec 23 2003
Externally publishedYes

Fingerprint

Catheter Ablation
Ventricular Fibrillation
Rabbits
Papillary Muscles
Propranolol
Action Potentials
Cytochalasins
Endocardium
Pericardium
Adrenergic Receptors
Control Groups

Keywords

  • Arrhythmia
  • Catheter ablation
  • Fibrillation
  • Mapping
  • Ventricles

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Catheter Ablation of Ventricular Fibrillation in Rabbit Ventricles Treated with β-Blockers. / Pak, Hui Nam; Oh, Yong Seog; Liu, Yen Bin; Wu, Tsu Juey; Karagueuzian, Hrayr S.; Lin, Shien-Fong; Chen, Peng-Sheng.

In: Circulation, Vol. 108, No. 25, 23.12.2003, p. 3149-3156.

Research output: Contribution to journalArticle

Pak, Hui Nam ; Oh, Yong Seog ; Liu, Yen Bin ; Wu, Tsu Juey ; Karagueuzian, Hrayr S. ; Lin, Shien-Fong ; Chen, Peng-Sheng. / Catheter Ablation of Ventricular Fibrillation in Rabbit Ventricles Treated with β-Blockers. In: Circulation. 2003 ; Vol. 108, No. 25. pp. 3149-3156.
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