Caudate, putamen, and globus pallidus volume in schizophrenia

A quantitative MRI study

Hiroto Hokama, Martha E. Shenton, Paul G. Nestor, Ron Kikinis, James J. Levitt, David Metcalf, Cynthia G. Wible, Brian O'Donnell, Ferenc A. Jolesz, Robert W. McCarley

Research output: Contribution to journalArticle

137 Citations (Scopus)

Abstract

Basal ganglia structures have been reported to be abnormal in schizophrenia. However, while component structures of the basal ganglia are functionally differentiated, there have been no evaluations of their separate magnetic resonance imaging (MRI) volumes with small voxel (1.5 min 3) spoiled gradient-recalled acquisition in steady state techniques and multi-plane assessments. We examined MRI scans from 15 male, right-handed, neuroleptic-medicated schizophrenic patients and 15 age-, handedness-, and gender-matched normal volunteers. Compared with normal subjects, schizophrenic patients showed enlarged volumes: 14.2% for total basal ganglia, 27.4% for globus pallidus, 15.9% for putamen, and 9.5% for caudate. Increased volumes, especially of the caudate, were associated with poorer neuropsychological test performance on finger tapping and Hebb's Recurring Digits. These findings indicate abnormalities throughout all basal ganglia structures in at least a subgroup of schizophrenic patients.

Original languageEnglish (US)
Pages (from-to)209-229
Number of pages21
JournalPsychiatry Research - Neuroimaging
Volume61
Issue number4
DOIs
StatePublished - Nov 10 1995
Externally publishedYes

Fingerprint

Globus Pallidus
Putamen
Basal Ganglia
Schizophrenia
Magnetic Resonance Imaging
Functional Laterality
Neuropsychological Tests
Antipsychotic Agents
Fingers
Healthy Volunteers

Keywords

  • Basal ganglia
  • Magnetic resonance imaging
  • Neuropsychology

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Radiology Nuclear Medicine and imaging
  • Neuroscience (miscellaneous)
  • Biological Psychiatry
  • Psychology(all)

Cite this

Hokama, H., Shenton, M. E., Nestor, P. G., Kikinis, R., Levitt, J. J., Metcalf, D., ... McCarley, R. W. (1995). Caudate, putamen, and globus pallidus volume in schizophrenia: A quantitative MRI study. Psychiatry Research - Neuroimaging, 61(4), 209-229. https://doi.org/10.1016/0925-4927(95)02729-H

Caudate, putamen, and globus pallidus volume in schizophrenia : A quantitative MRI study. / Hokama, Hiroto; Shenton, Martha E.; Nestor, Paul G.; Kikinis, Ron; Levitt, James J.; Metcalf, David; Wible, Cynthia G.; O'Donnell, Brian; Jolesz, Ferenc A.; McCarley, Robert W.

In: Psychiatry Research - Neuroimaging, Vol. 61, No. 4, 10.11.1995, p. 209-229.

Research output: Contribution to journalArticle

Hokama, H, Shenton, ME, Nestor, PG, Kikinis, R, Levitt, JJ, Metcalf, D, Wible, CG, O'Donnell, B, Jolesz, FA & McCarley, RW 1995, 'Caudate, putamen, and globus pallidus volume in schizophrenia: A quantitative MRI study', Psychiatry Research - Neuroimaging, vol. 61, no. 4, pp. 209-229. https://doi.org/10.1016/0925-4927(95)02729-H
Hokama, Hiroto ; Shenton, Martha E. ; Nestor, Paul G. ; Kikinis, Ron ; Levitt, James J. ; Metcalf, David ; Wible, Cynthia G. ; O'Donnell, Brian ; Jolesz, Ferenc A. ; McCarley, Robert W. / Caudate, putamen, and globus pallidus volume in schizophrenia : A quantitative MRI study. In: Psychiatry Research - Neuroimaging. 1995 ; Vol. 61, No. 4. pp. 209-229.
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