CD1 recognition by mouse NK1+ T lymphocytes

Albert Bendelac, Olivier Lantz, Mary E. Quimby, Jonathan W. Yewdell, Jack R. Bennink, Randy Brutkiewicz

Research output: Contribution to journalArticle

799 Citations (Scopus)

Abstract

Rare major histocompatibility complex (MHC) class I-like CD1-specific T cells have been isolated from human blood, but it has not been determined whether these clones are part of a defined subset of CD1-specific T cells selected during T cell development, or whether their recognition of CD1 is a fortuitous cross-reaction. In mice, an entire subset of αβ thymocytes with a unique phenotype was found to be CD1-specific. This particular subset, and its human counterpart, provide evidence that CD1 has a general role in selecting and interacting with specialized αβ T cells.

Original languageEnglish (US)
Pages (from-to)863-865
Number of pages3
JournalScience
Volume268
Issue number5212
StatePublished - 1995
Externally publishedYes

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T-Lymphocytes
Cross Reactions
Thymocytes
Major Histocompatibility Complex
Clone Cells
Phenotype

ASJC Scopus subject areas

  • General

Cite this

Bendelac, A., Lantz, O., Quimby, M. E., Yewdell, J. W., Bennink, J. R., & Brutkiewicz, R. (1995). CD1 recognition by mouse NK1+ T lymphocytes. Science, 268(5212), 863-865.

CD1 recognition by mouse NK1+ T lymphocytes. / Bendelac, Albert; Lantz, Olivier; Quimby, Mary E.; Yewdell, Jonathan W.; Bennink, Jack R.; Brutkiewicz, Randy.

In: Science, Vol. 268, No. 5212, 1995, p. 863-865.

Research output: Contribution to journalArticle

Bendelac, A, Lantz, O, Quimby, ME, Yewdell, JW, Bennink, JR & Brutkiewicz, R 1995, 'CD1 recognition by mouse NK1+ T lymphocytes', Science, vol. 268, no. 5212, pp. 863-865.
Bendelac A, Lantz O, Quimby ME, Yewdell JW, Bennink JR, Brutkiewicz R. CD1 recognition by mouse NK1+ T lymphocytes. Science. 1995;268(5212):863-865.
Bendelac, Albert ; Lantz, Olivier ; Quimby, Mary E. ; Yewdell, Jonathan W. ; Bennink, Jack R. ; Brutkiewicz, Randy. / CD1 recognition by mouse NK1+ T lymphocytes. In: Science. 1995 ; Vol. 268, No. 5212. pp. 863-865.
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