CD1 recognition by mouse NK1+ T lymphocytes

Albert Bendelac, Olivier Lantz, Mary E. Quimby, Jonathan W. Yewdell, Jack R. Bennink, Randy R. Brutkiewicz

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802 Scopus citations

Abstract

Rare major histocompatibility complex (MHC) class I-like CD1-specific T cells have been isolated from human blood, but it has not been determined whether these clones are part of a defined subset of CD1-specific T cells selected during T cell development, or whether their recognition of CD1 is a fortuitous cross-reaction. In mice, an entire subset of αβ thymocytes with a unique phenotype was found to be CD1-specific. This particular subset, and its human counterpart, provide evidence that CD1 has a general role in selecting and interacting with specialized αβ T cells.

Original languageEnglish (US)
Pages (from-to)863-865
Number of pages3
JournalScience
Volume268
Issue number5212
DOIs
StatePublished - Jan 1 1995
Externally publishedYes

ASJC Scopus subject areas

  • General

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    Bendelac, A., Lantz, O., Quimby, M. E., Yewdell, J. W., Bennink, J. R., & Brutkiewicz, R. R. (1995). CD1 recognition by mouse NK1+ T lymphocytes. Science, 268(5212), 863-865. https://doi.org/10.1126/science.7538697