Purpose of Review: Many surface antigens have been previously used to identify hematopoietic stem cells or cellular elements of the hematopoietic niche. However, to date, not a single surface marker has been identified as a common marker expressed on murine and human hematopoietic stem cells and on cells of the hematopoietic niche. Recently, a few laboratories, including ours, recognized the importance of CD166 as a functional marker on both stem cells and osteoblasts and have begun to characterize the role of CD166 in hematopoiesis. RECENT FINDINGS: Expression of CD166 on hematopoietic cells and cells in the marrow microenvironment was first reported more than a decade ago. Lately, however, a more prominent role for CD166 in normal hematopoiesis and in cancer biology including metastasis began to emerge. This review will cover the significance of CD166 in identifying normal hematopoietic stem cells and cells of the hematopoietic niche and highlight how CD166-mediated homophilic interactions between both cell types may be critical for stem cell function. SUMMARY: The conserved homology between murine and human CD166 and its involvement in metastasis provides an excellent bridge for translational investigations aimed at enhancing stem cell engraftment and clinical utility of stem cells and at using CD166 as a therapeutic target in cancer.
- Activated leukocyte cell adhesion molecule
- Hematopoietic niche
- Hematopoietic stem cells
ASJC Scopus subject areas
TY - JOUR
T1 - CD166 and regulation of hematopoiesis
AU - Chitteti, Brahmananda R.
AU - Bethel, Monique
AU - Kacena, Melissa
AU - Srour, Edward
PY - 2013/7
Y1 - 2013/7
N2 - Lippincott Williams & Wilkins.
AB - Lippincott Williams & Wilkins.
KW - Activated leukocyte cell adhesion molecule
KW - CD166
KW - Hematopoiesis
KW - Hematopoietic niche
KW - Hematopoietic stem cells
UR - http://www.scopus.com/inward/record.url?scp=84880243275&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84880243275&partnerID=8YFLogxK
U2 - 10.1097/MOH.0b013e32836060a9
DO - 10.1097/MOH.0b013e32836060a9
M3 - Article
VL - 20
SP - 273
EP - 280
JO - Current Opinion in Hematology
JF - Current Opinion in Hematology
SN - 1065-6251
IS - 4