CD1d ligands: The good, the bad, and the ugly

Research output: Contribution to journalReview article

137 Scopus citations


The MHC class I-like CD1d glycoprotein is a member of the CD1 family of Ag-presenting molecules and is responsible for the selection of NKT cells. A number of ligands that can be presented by CD1d to NKT or other CD1d-restricted T cells have been identified. These include glycolipids from a marine sponge, bacterial glycolipids, normal endogenous glycolipids, tumor-derived phospholipids and glycolipids, and nonlipidic molecules. The presentation of many of these molecules can have immunopotentiating effects, such as serving as an adjuvant against malaria or resulting in a more rapid clearance of certain virus infections. They can also be protective in autoimmune diseases or cancer or can be deleterious. This review will highlight these ligands in a discussion of their potential use against (and role in the pathogenesis of) these diseases.

Original languageEnglish (US)
Pages (from-to)769-775
Number of pages7
JournalJournal of Immunology
Issue number2
StatePublished - Jul 15 2006

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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