CD1d ligands: The good, the bad, and the ugly

Research output: Contribution to journalArticle

135 Citations (Scopus)

Abstract

The MHC class I-like CD1d glycoprotein is a member of the CD1 family of Ag-presenting molecules and is responsible for the selection of NKT cells. A number of ligands that can be presented by CD1d to NKT or other CD1d-restricted T cells have been identified. These include glycolipids from a marine sponge, bacterial glycolipids, normal endogenous glycolipids, tumor-derived phospholipids and glycolipids, and nonlipidic molecules. The presentation of many of these molecules can have immunopotentiating effects, such as serving as an adjuvant against malaria or resulting in a more rapid clearance of certain virus infections. They can also be protective in autoimmune diseases or cancer or can be deleterious. This review will highlight these ligands in a discussion of their potential use against (and role in the pathogenesis of) these diseases.

Original languageEnglish
Pages (from-to)769-775
Number of pages7
JournalJournal of Immunology
Volume177
Issue number2
StatePublished - Jul 15 2006

Fingerprint

Glycolipids
Ligands
Natural Killer T-Cells
Porifera
Virus Diseases
Autoimmune Diseases
Malaria
Neoplasms
Phospholipids
Glycoproteins
T-Lymphocytes

ASJC Scopus subject areas

  • Immunology

Cite this

CD1d ligands : The good, the bad, and the ugly. / Brutkiewicz, Randy.

In: Journal of Immunology, Vol. 177, No. 2, 15.07.2006, p. 769-775.

Research output: Contribution to journalArticle

@article{97287468473245f494d4d7d5d64a9dc5,
title = "CD1d ligands: The good, the bad, and the ugly",
abstract = "The MHC class I-like CD1d glycoprotein is a member of the CD1 family of Ag-presenting molecules and is responsible for the selection of NKT cells. A number of ligands that can be presented by CD1d to NKT or other CD1d-restricted T cells have been identified. These include glycolipids from a marine sponge, bacterial glycolipids, normal endogenous glycolipids, tumor-derived phospholipids and glycolipids, and nonlipidic molecules. The presentation of many of these molecules can have immunopotentiating effects, such as serving as an adjuvant against malaria or resulting in a more rapid clearance of certain virus infections. They can also be protective in autoimmune diseases or cancer or can be deleterious. This review will highlight these ligands in a discussion of their potential use against (and role in the pathogenesis of) these diseases.",
author = "Randy Brutkiewicz",
year = "2006",
month = "7",
day = "15",
language = "English",
volume = "177",
pages = "769--775",
journal = "Journal of Immunology",
issn = "0022-1767",
publisher = "American Association of Immunologists",
number = "2",

}

TY - JOUR

T1 - CD1d ligands

T2 - The good, the bad, and the ugly

AU - Brutkiewicz, Randy

PY - 2006/7/15

Y1 - 2006/7/15

N2 - The MHC class I-like CD1d glycoprotein is a member of the CD1 family of Ag-presenting molecules and is responsible for the selection of NKT cells. A number of ligands that can be presented by CD1d to NKT or other CD1d-restricted T cells have been identified. These include glycolipids from a marine sponge, bacterial glycolipids, normal endogenous glycolipids, tumor-derived phospholipids and glycolipids, and nonlipidic molecules. The presentation of many of these molecules can have immunopotentiating effects, such as serving as an adjuvant against malaria or resulting in a more rapid clearance of certain virus infections. They can also be protective in autoimmune diseases or cancer or can be deleterious. This review will highlight these ligands in a discussion of their potential use against (and role in the pathogenesis of) these diseases.

AB - The MHC class I-like CD1d glycoprotein is a member of the CD1 family of Ag-presenting molecules and is responsible for the selection of NKT cells. A number of ligands that can be presented by CD1d to NKT or other CD1d-restricted T cells have been identified. These include glycolipids from a marine sponge, bacterial glycolipids, normal endogenous glycolipids, tumor-derived phospholipids and glycolipids, and nonlipidic molecules. The presentation of many of these molecules can have immunopotentiating effects, such as serving as an adjuvant against malaria or resulting in a more rapid clearance of certain virus infections. They can also be protective in autoimmune diseases or cancer or can be deleterious. This review will highlight these ligands in a discussion of their potential use against (and role in the pathogenesis of) these diseases.

UR - http://www.scopus.com/inward/record.url?scp=33745838249&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33745838249&partnerID=8YFLogxK

M3 - Article

C2 - 16818729

AN - SCOPUS:33745838249

VL - 177

SP - 769

EP - 775

JO - Journal of Immunology

JF - Journal of Immunology

SN - 0022-1767

IS - 2

ER -