CD1d-Mediated Antigen Presentation to Natural Killer T (NKT) Cells

Randy R. Brutkiewicz, Yinling Lin, Sungyoo Cho, Yu Kyeong Hwang, Venkataraman Sriram, Tonya J. Roberts

Research output: Contribution to journalReview article

40 Scopus citations


CD1d molecules are lipid antigen-presenting molecules. They are involved in presenting these antigens to a unique subpopulation of T cells called natural killer T (NKT) cells, which have the capacity to produce both T helper (Th) 1 and Th2 cytokines. Thus, it is possible that the antigens presented by CD1d and/or the level at which they are presented could have profound effects on the immunoregulation of autoimmune and infectious diseases, as well as cancer. Because of the ability of CD1d-binding ligands to modulate NKT cell responses, targeting CD1d-mediated antigen presentation as a novel approach for new therapies in these and other diseases holds great promise.

Original languageEnglish (US)
Pages (from-to)403-419
Number of pages17
JournalCritical reviews in immunology
Issue number5-6
StatePublished - 2003


  • Antigen presentation
  • Autoimmunity
  • Cancer
  • CD1d
  • Infectious diseases
  • NKT cells

ASJC Scopus subject areas

  • Immunology

Fingerprint Dive into the research topics of 'CD1d-Mediated Antigen Presentation to Natural Killer T (NKT) Cells'. Together they form a unique fingerprint.

  • Cite this