CD4+ T-cell-mediated anti-tumor immunity can be uncoupled from autoimmunity via the STAT4/STAT6 signaling axis

Sheng Zhang, Dannie Bernard, Waliul I. Khan, Mark Kaplan, Jonathan L. Bramson, Yonghong Wan

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Previous reports have suggested that autoimmune sequelae may be an unavoidable consequence of successful immunization against tumor-associated antigens, which are typically non-mutated self-antigens. Using a melanoma model, we demonstrated that CD4+ T-cell-mediated anti-tumor immunity and autoimmunity could be separated by modulating the STAT4/STAT6 signaling axis. Our results have revealed an unexpected dichotomy in the effector phase following cancer vaccination where anti-tumor immunity is mediated via a STAT6 and IL-4-dependent pathway, whereas autoimmune pathology is mediated via STAT4 through a mechanism that relies partially on IFN-γ. Our results offer a possibility to elicit specific anti-tumor responses without triggering unwanted tissue autoimmune diseases.

Original languageEnglish
Pages (from-to)1252-1259
Number of pages8
JournalEuropean Journal of Immunology
Volume39
Issue number5
DOIs
StatePublished - May 2009

Fingerprint

Autoimmunity
Immunity
T-Lymphocytes
Neoplasms
Autoantigens
Neoplasm Antigens
Interleukin-4
Autoimmune Diseases
Melanoma
Immunization
Vaccination
Pathology

Keywords

  • Anti-tumor immunity
  • Autoimmunity
  • CD4 T cells
  • Cytokines
  • Vaccination

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

CD4+ T-cell-mediated anti-tumor immunity can be uncoupled from autoimmunity via the STAT4/STAT6 signaling axis. / Zhang, Sheng; Bernard, Dannie; Khan, Waliul I.; Kaplan, Mark; Bramson, Jonathan L.; Wan, Yonghong.

In: European Journal of Immunology, Vol. 39, No. 5, 05.2009, p. 1252-1259.

Research output: Contribution to journalArticle

Zhang, Sheng ; Bernard, Dannie ; Khan, Waliul I. ; Kaplan, Mark ; Bramson, Jonathan L. ; Wan, Yonghong. / CD4+ T-cell-mediated anti-tumor immunity can be uncoupled from autoimmunity via the STAT4/STAT6 signaling axis. In: European Journal of Immunology. 2009 ; Vol. 39, No. 5. pp. 1252-1259.
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