CD4+CD25+ regulatory T cells and CD1-restricted NKT cells do not mediate facial motoneuron survival after axotomy

Cynthia A. DeBoy, Susanna C. Byram, Craig J. Serpe, Danielle Wisuri, Virginia M. Sanders, Kathryn J. Jones

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

CD4+ T cells rescue facial motoneurons (FMN) from axotomy-induced cell death. The objective of this study is to determine if the CD4+ T regulatory subsets, CD4+CD25+ T or CD1d-restricted NKT cells are critical for FMN survival after facial nerve axotomy. Surviving FMN within facial motor nuclei from axotomized and control sides 4 weeks after axotomy were counted to determine percent FMN survival. Data generated by applying this paradigm to recombination activating gene-2-deficient mice reconstituted with CD4+ T cells depleted of CD4+CD25+ T cells and to CD1-/- mice, deficient in CD1d-restricted NKT cells, suggest that neither regulatory CD4+ T subset is critical for FMN survival.

Original languageEnglish (US)
Pages (from-to)34-38
Number of pages5
JournalJournal of Neuroimmunology
Volume176
Issue number1-2
DOIs
StatePublished - Jul 1 2006

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Keywords

  • CD1-restricted NKT cell
  • CD4+ regulatory T cell
  • Facial nerve axotomy
  • Motoneuron survival

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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