Cdk5 activity in the brain - multiple paths of regulation

Kavita Shah, Debomoy K. Lahiri

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Cyclin dependent kinase-5 (Cdk5), a family member of the cyclindependent kinases, plays a pivotal role in the central nervous system. During embryogenesis, Cdk5 is indispensable for brain development and, in the adult brain, it is essential for numerous neuronal processes, including higher cognitive functions such as learning and memory formation. However, Cdk5 activity becomes deregulated in several neurological disorders, such as Alzheimer's disease, Parkinson's disease and Huntington's disease, which leads to neurotoxicity. Therefore, precise control over Cdk5 activity is essential for its physiological functions. This Commentary covers the various mechanisms of Cdk5 regulation, including several recently identified protein activators and inhibitors of Cdk5 that control its activity in normal and diseased brains. We also discuss the autoregulatory activity of Cdk5 and its regulation at the transcriptional, post-transcriptional and post-translational levels. We finally highlight physiological and pathological roles of Cdk5 in the brain. Specific modulation of these protein regulators is expected to provide alternative strategies for the development of effective therapeutic interventions that are triggered by deregulation of Cdk5.

Original languageEnglish (US)
Pages (from-to)2407-2419
Number of pages13
JournalJournal of cell science
Volume127
Issue number11
DOIs
StatePublished - Jun 2014

Keywords

  • Alzheimer's disease
  • Axonal growth
  • Cdk
  • Cdk5
  • Cyclins
  • Excitotoxicity
  • Learning and memory
  • Neurodegeneration
  • Neuronal migration
  • P25
  • P35
  • Pain signalling
  • Synaptic plasticity
  • Synaptogenesis
  • β-Amyloid

ASJC Scopus subject areas

  • Cell Biology

Fingerprint Dive into the research topics of 'Cdk5 activity in the brain - multiple paths of regulation'. Together they form a unique fingerprint.

  • Cite this