Cdk5 activity in the brain - multiple paths of regulation

Kavita Shah, Debomoy Lahiri

Research output: Contribution to journalReview article

42 Citations (Scopus)

Abstract

Cyclin dependent kinase-5 (Cdk5), a family member of the cyclin-dependent kinases, plays a pivotal role in the central nervous system. During embryogenesis, Cdk5 is indispensable for brain development and, in the adult brain, it is essential for numerous neuronal processes, including higher cognitive functions such as learning and memory formation. However, Cdk5 activity becomes deregulated in several neurological disorders, such as Alzheimer's disease, Parkinson's disease and Huntington's disease, which leads to neurotoxicity. Therefore, precise control over Cdk5 activity is essential for its physiological functions. This Commentary covers the various mechanisms of Cdk5 regulation, including several recently identified protein activators and inhibitors of Cdk5 that control its activity in normal and diseased brains. We also discuss the autoregulatory activity of Cdk5 and its regulation at the transcriptional, post-transcriptional and post-translational levels. We finally highlight physiological and pathological roles of Cdk5 in the brain. Specific modulation of these protein regulators is expected to provide alternative strategies for the development of effective therapeutic interventions that are triggered by deregulation of Cdk5.

Original languageEnglish (US)
Pages (from-to)2391-2400
Number of pages10
JournalJournal of Cell Science
Volume127
DOIs
StatePublished - Jun 1 2014

Fingerprint

Cyclin-Dependent Kinase 5
Brain
Cyclin-Dependent Kinases
Huntington Disease
Brain Diseases
Nervous System Diseases
Cognition
Embryonic Development
Parkinson Disease
Alzheimer Disease
Proteins
Central Nervous System
Learning

Keywords

  • Alzheimer’s disease
  • Axonal growth
  • Cdk
  • Cdk5
  • Cyclins
  • Excitotoxicity
  • Learning and memory
  • Neurodegeneration
  • Neuronal migration
  • p25
  • p35
  • Pain signalling
  • Synaptic plasticity
  • Synaptogenesis
  • β-Amyloid

ASJC Scopus subject areas

  • Cell Biology

Cite this

Cdk5 activity in the brain - multiple paths of regulation. / Shah, Kavita; Lahiri, Debomoy.

In: Journal of Cell Science, Vol. 127, 01.06.2014, p. 2391-2400.

Research output: Contribution to journalReview article

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