Celiac disease as a possible cause for low serum ferritin in patients with restless legs syndrome

Shalini Manchanda, Charles R. Davies, Daniel Picchietti

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Objective: To describe celiac disease (CD) as a possible cause for low serum ferritin in patients with restless legs syndrome (RLS). Background: Low iron stores have been found to be a risk factor for RLS with serum ferritin levels less than 45-50 ng/mL associated with increased severity of RLS. It has become routine clinical practice to test serum ferritin in the initial assessment of RLS. CD is a common genetic disorder that can cause iron deficiency. Methods: Consecutive case series of four patients with RLS and serum ferritin below 25 ng/mL, who had positive screening tests for celiac disease. Results: We report four patients who had serum ferritin <12 ng/mL and positive screening tests for CD. All had CD confirmed by duodenal biopsy and response to a gluten-free diet. RLS symptoms improved in all four, with two able to discontinue RLS medication and two responding without medication. Conclusions: In patients with RLS and low serum ferritin who do not have an obvious cause for iron deficiency, we suggest looking for CD by simple, inexpensive serologic testing. Diagnosis and treatment of CD is likely to improve the outcome for RLS, as well as identify individuals who are at risk for the significant long-term complications of CD.

Original languageEnglish (US)
Pages (from-to)763-765
Number of pages3
JournalSleep Medicine
Volume10
Issue number7
DOIs
StatePublished - Aug 1 2009

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Restless Legs Syndrome
Celiac Disease
Ferritins
Serum
Iron
Gluten-Free Diet
Inborn Genetic Diseases
Biopsy

Keywords

  • Celiac disease
  • Ferritin
  • Gluten
  • Iron deficiency
  • Iron supplementation
  • Malabsorption
  • Restless legs syndrome
  • Tissue transglutaminase

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Celiac disease as a possible cause for low serum ferritin in patients with restless legs syndrome. / Manchanda, Shalini; Davies, Charles R.; Picchietti, Daniel.

In: Sleep Medicine, Vol. 10, No. 7, 01.08.2009, p. 763-765.

Research output: Contribution to journalArticle

Manchanda, Shalini ; Davies, Charles R. ; Picchietti, Daniel. / Celiac disease as a possible cause for low serum ferritin in patients with restless legs syndrome. In: Sleep Medicine. 2009 ; Vol. 10, No. 7. pp. 763-765.
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