Cell-based approaches for cardiac repair

Research output: Chapter in Book/Report/Conference proceedingConference contribution

24 Scopus citations

Abstract

Many forms of cardiovascular disease are associated with cardiomyocyte loss via necrosis and/or apoptosis. The cumulative loss of contractile cells ultimately results in diminished cardiac function. Numerous approaches have been employed to reduce the rate of cardiomyocyte loss, or alternatively, to repopulate the heart with new cardiomyocytes. Strategies aimed at repopulating the heart include cardiomyocyte cell therapy, myogenic stem cell therapy, and cell cycle activation therapy. All three approaches are based on the assumption that the de novo cardiomyocytes will participate in a functional syncytium with the surviving myocardium. This review will discuss the current status of interventions aimed at repopulating the heart with functional cardiomyocytes.

Original languageEnglish (US)
Title of host publicationInteractive and Integrative Cardiology
PublisherBlackwell Publishing Inc.
Pages34-48
Number of pages15
ISBN (Print)1573316512, 9781573316514
DOIs
StatePublished - Oct 2006

Publication series

NameAnnals of the New York Academy of Sciences
Volume1080
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

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Keywords

  • Apoptosis
  • Cardiomyocyte proliferation
  • Myocardial regeneration
  • Stem cells

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Rubart, M., & Field, L. J. (2006). Cell-based approaches for cardiac repair. In Interactive and Integrative Cardiology (pp. 34-48). (Annals of the New York Academy of Sciences; Vol. 1080). Blackwell Publishing Inc.. https://doi.org/10.1196/annals.1380.004