Cell-based approaches for cardiac repair

Research output: Chapter in Book/Report/Conference proceedingConference contribution

24 Citations (Scopus)

Abstract

Many forms of cardiovascular disease are associated with cardiomyocyte loss via necrosis and/or apoptosis. The cumulative loss of contractile cells ultimately results in diminished cardiac function. Numerous approaches have been employed to reduce the rate of cardiomyocyte loss, or alternatively, to repopulate the heart with new cardiomyocytes. Strategies aimed at repopulating the heart include cardiomyocyte cell therapy, myogenic stem cell therapy, and cell cycle activation therapy. All three approaches are based on the assumption that the de novo cardiomyocytes will participate in a functional syncytium with the surviving myocardium. This review will discuss the current status of interventions aimed at repopulating the heart with functional cardiomyocytes.

Original languageEnglish
Title of host publicationAnnals of the New York Academy of Sciences
Pages34-48
Number of pages15
Volume1080
DOIs
StatePublished - Oct 2006

Publication series

NameAnnals of the New York Academy of Sciences
Volume1080
ISSN (Print)00778923
ISSN (Electronic)17496632

Fingerprint

Cardiac Myocytes
Repair
Cell- and Tissue-Based Therapy
Stem cells
Chemical activation
Cells
Apoptosis
Giant Cells
Myocardium
Cell Cycle
Necrosis
Cardiovascular Diseases
Stem Cells

Keywords

  • Apoptosis
  • Cardiomyocyte proliferation
  • Myocardial regeneration
  • Stem cells

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Rubart-von der Lohe, M., & Field, L. (2006). Cell-based approaches for cardiac repair. In Annals of the New York Academy of Sciences (Vol. 1080, pp. 34-48). (Annals of the New York Academy of Sciences; Vol. 1080). https://doi.org/10.1196/annals.1380.004

Cell-based approaches for cardiac repair. / Rubart-von der Lohe, Michael; Field, Loren.

Annals of the New York Academy of Sciences. Vol. 1080 2006. p. 34-48 (Annals of the New York Academy of Sciences; Vol. 1080).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Rubart-von der Lohe, M & Field, L 2006, Cell-based approaches for cardiac repair. in Annals of the New York Academy of Sciences. vol. 1080, Annals of the New York Academy of Sciences, vol. 1080, pp. 34-48. https://doi.org/10.1196/annals.1380.004
Rubart-von der Lohe M, Field L. Cell-based approaches for cardiac repair. In Annals of the New York Academy of Sciences. Vol. 1080. 2006. p. 34-48. (Annals of the New York Academy of Sciences). https://doi.org/10.1196/annals.1380.004
Rubart-von der Lohe, Michael ; Field, Loren. / Cell-based approaches for cardiac repair. Annals of the New York Academy of Sciences. Vol. 1080 2006. pp. 34-48 (Annals of the New York Academy of Sciences).
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