Cell-Cell Communication Breakdown and Endothelial Dysfunction

Daniel D. Lee, Margaret A. Schwarz

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

Guided by organ-specific signals in both development and disease response, the heterogeneous endothelial cell population is a dynamic member of the vasculature. Functioning as the gatekeeper to fluid, inflammatory cells, oxygen, and nutrients, endothelial cell communication with its local environment is critical. Impairment of endothelial cell-cell communication not only disrupts this signaling process, but also contributes to pathologic disease progression. Expanding our understanding of those processes that mediate endothelial cell-cell communication is an important step in the approach to treatment of disease processes.

Original languageEnglish (US)
Pages (from-to)189-200
Number of pages12
JournalCritical Care Clinics
Volume36
Issue number2
DOIs
StatePublished - Apr 2020
Externally publishedYes

Keywords

  • Development
  • Disease
  • Dysfunction
  • Endothelium
  • Heterogeneity
  • Signaling

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Fingerprint Dive into the research topics of 'Cell-Cell Communication Breakdown and Endothelial Dysfunction'. Together they form a unique fingerprint.

Cite this