Cell-Cell Communication Breakdown and Endothelial Dysfunction

Daniel D. Lee, Margaret A. Schwarz

Research output: Contribution to journalReview article

1 Scopus citations


Guided by organ-specific signals in both development and disease response, the heterogeneous endothelial cell population is a dynamic member of the vasculature. Functioning as the gatekeeper to fluid, inflammatory cells, oxygen, and nutrients, endothelial cell communication with its local environment is critical. Impairment of endothelial cell-cell communication not only disrupts this signaling process, but also contributes to pathologic disease progression. Expanding our understanding of those processes that mediate endothelial cell-cell communication is an important step in the approach to treatment of disease processes.

Original languageEnglish (US)
Pages (from-to)189-200
Number of pages12
JournalCritical Care Clinics
Issue number2
StatePublished - Apr 2020
Externally publishedYes


  • Development
  • Disease
  • Dysfunction
  • Endothelium
  • Heterogeneity
  • Signaling

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

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