Cell-cycle-based strategies to drive myocardial repair

Wuqiang Zhu, Rutger J. Hassink, Michael Rubart, Loren J. Field

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Cardiomyocytes exhibit robust proliferative activity during development. After birth, cardiomyocyte proliferation is markedly reduced. Consequently, regenerative growth in the postnatal heart via cardiomyocyte proliferation (and, by inference, proliferation of stem-cell-derived cardiomyocytes) is limited and often insufficient to affect repair following injury. Here, we review studies wherein cardiomyocyte cell cycle proliferation was induced via targeted expression of cyclin D2 in postnatal hearts. Cyclin D2 expression resulted in a greater than 500-fold increase in cell cycle activity in transgenic mice as compared to their nontransgenic siblings. Induced cell cycle activity resulted in infarct regression and concomitant improvement in cardiac hemodynamics following coronary artery occlusion. These studies support the notion that cell-cycle-based strategies can be exploited to drive myocardial repair following injury.

Original languageEnglish (US)
Pages (from-to)710-715
Number of pages6
JournalPediatric Cardiology
Volume30
Issue number5
DOIs
StatePublished - Jul 1 2009

Keywords

  • Cardiomyocyte proliferation
  • Cell cycle
  • Heart regeneration

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pediatrics, Perinatology, and Child Health

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