Cell Cycle-Mediated Cardiac Regeneration in the Mouse Heart

Arash Eghbali, Austin Dukes, Karl Toischer, Gerd Hasenfuss, Loren Field

Research output: Contribution to journalReview article

Abstract

PURPOSE OF REVIEW: Many forms of heart disease result in the essentially irreversible loss of cardiomyocytes. The ability to promote cardiomyocyte renewal may be a promising approach to reverse injury in diseased hearts. The purpose of this review is to describe the impact of cardiomyocyte cell cycle activation on cardiac function and structure in several different models of myocardial disease. RECENT FINDINGS: Transgenic mice expressing cyclin D2 (D2 mice) exhibit sustained cardiomyocyte renewal in the adult heart. Earlier studies demonstrated that D2 mice exhibited progressive myocardial regeneration in experimental models of myocardial infarction, and that cardiac function was normalized to values seen in sham-operated litter mates by 180 days post-injury. D2 mice also exhibited markedly improved atrial structure in a genetic model of atrial fibrosis. More recent studies revealed that D2 mice were remarkably resistant to heart failure induced by chronic elevated afterload as compared with their wild type (WT siblings), with a 6-fold increase in median survival as well as retention of relatively normal cardiac function. Finally, D2 mice exhibited a progressive recovery in cardiac function to normal levels and a concomitant reduction in adverse myocardial remodeling in an anthracycline cardiotoxicity model. The studies reviewed here make a strong case for the potential utility of inducing cardiomyocyte renewal as a means to treat injured hearts. Several challenges which must be met to develop a viable therapeutic intervention based on these observations are discussed.

Original languageEnglish (US)
Number of pages1
JournalCurrent cardiology reports
Volume21
Issue number10
DOIs
StatePublished - Sep 16 2019

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Cardiac Myocytes
Regeneration
Cell Cycle
Heart Diseases
Cyclin D2
Anthracyclines
Genetic Models
Wounds and Injuries
Cardiomyopathies
Transgenic Mice
Fibrosis
Theoretical Models
Heart Failure
Myocardial Infarction
Therapeutics

Keywords

  • Cardiac regeneration
  • Cardiomyocyte renewal
  • Cell cycle regulation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Cell Cycle-Mediated Cardiac Regeneration in the Mouse Heart. / Eghbali, Arash; Dukes, Austin; Toischer, Karl; Hasenfuss, Gerd; Field, Loren.

In: Current cardiology reports, Vol. 21, No. 10, 16.09.2019.

Research output: Contribution to journalReview article

Eghbali, Arash ; Dukes, Austin ; Toischer, Karl ; Hasenfuss, Gerd ; Field, Loren. / Cell Cycle-Mediated Cardiac Regeneration in the Mouse Heart. In: Current cardiology reports. 2019 ; Vol. 21, No. 10.
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