Cell cycle regulation of the Saccharomyces cerevisiae polo-like kinase Cdc5p

Liang Cheng, Linda Hunke, Christopher F.J. Hardy

Research output: Contribution to journalArticle

91 Scopus citations

Abstract

Progression through and completion of mitosis require the actions of the evolutionarily conserved Polo kinase. We have determined that the levels of Cdc5p, a Saccharomyces cerevisiae member of the Polo family of mitotic kinases, are cell cycle regulated. Cdc5p accumulates in the nuclei of G2/M- phase cells, and its levels decline dramatically as cells progress through anaphase and begin telophase. We report that Cdc5p levels are sensitive to mutations in key components of the anaphase-promoting complex (APC). We have determined that Cdc5p-associated kinase activity is restricted to G2/M and that this activity is posttranslationally regulated. These results further link the actions of the APC to the completion of mitosis and suggest possible roles for CdcSp during progression through and completion of mitosis.

Original languageEnglish (US)
Pages (from-to)7360-7370
Number of pages11
JournalMolecular and cellular biology
Volume18
Issue number12
DOIs
StatePublished - Dec 1998
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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