Cellular accommodation and the response of bone to mechanical loading

Jennifer L. Schriefer, Stuart J. Warden, Leanne K. Saxon, Alexander Robling, Charles H. Turner

Research output: Contribution to journalArticle

100 Citations (Scopus)

Abstract

Several mathematical rules by which bone adapts to mechanical loading have been proposed. Previous work focused mainly on negative feedback models, e.g., bone adapts to increased loading after a minimum strain effective (MES) threshold has been reached. The MES algorithm has numerous caveats, so we propose a different model, according to which bone adapts to changes in its mechanical environment based on the principle of cellular accommodation. With the new algorithm we presume that strain history is integrated into cellular memory so that the reference state for adaptation is constantly changing. To test this algorithm, an experiment was performed in which the ulnae of Sprague-Dawley rats were loaded in axial compression. The animals received loading for 15 weeks with progressively decreasing loads, increasing loads, or a constant load. The results showed the largest increases in geometry in the decreasing load group, followed by the constant load group. Bone formation rates (BFRs) were significantly greater in the decreasing load group during the first 2 weeks of the study as compared to all other groups (P

Original languageEnglish (US)
Pages (from-to)1838-1845
Number of pages8
JournalJournal of Biomechanics
Volume38
Issue number9
DOIs
StatePublished - Sep 2005

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Bone
Bone and Bones
Ulna
Osteogenesis
Sprague Dawley Rats
Axial compression
History
Rats
Animals
Feedback
Data storage equipment
Geometry
Experiments

Keywords

  • Biomechanics
  • Bone density
  • Mechanical loading
  • Osteoporosis

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

Cite this

Cellular accommodation and the response of bone to mechanical loading. / Schriefer, Jennifer L.; Warden, Stuart J.; Saxon, Leanne K.; Robling, Alexander; Turner, Charles H.

In: Journal of Biomechanics, Vol. 38, No. 9, 09.2005, p. 1838-1845.

Research output: Contribution to journalArticle

Schriefer, Jennifer L. ; Warden, Stuart J. ; Saxon, Leanne K. ; Robling, Alexander ; Turner, Charles H. / Cellular accommodation and the response of bone to mechanical loading. In: Journal of Biomechanics. 2005 ; Vol. 38, No. 9. pp. 1838-1845.
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