Cellular and molecular mechanisms of sex differences in renal ischemia-reperfusion injury

Ajay Kher, Kirstan K. Meldrum, Meijing Wang, Ben M. Tsai, Jeffrey M. Pitcher, Daniel R. Meldrum

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Renal ischemia-reperfusion (I/R) is an important etiopathological mechanism of acute renal failure (ARF). Despite improvements in the treatment of ARF, it is associated with significant morbidity and mortality. I/R injury also occurs during renal transplantation and leads to reduced allograft survival. Sex differences have been found in I/R injury in many different organs including the kidney. Women have half the mortality of men in ARF. In animal models also, females are protected against renal I/R injury. The mechanisms by which sex affects the outcome to renal I/R injury are being actively investigated. This review will examine the evidence for gender differences in renal I/R injury and discuss the probable mechanisms by which sex affects the renal response to I/R injury.

Original languageEnglish
Pages (from-to)594-603
Number of pages10
JournalCardiovascular Research
Volume67
Issue number4
DOIs
StatePublished - Sep 1 2005

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Reperfusion Injury
Sex Characteristics
Kidney
Acute Kidney Injury
Mortality
Kidney Transplantation
Reperfusion
Allografts
Ischemia
Animal Models
Morbidity

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Cellular and molecular mechanisms of sex differences in renal ischemia-reperfusion injury. / Kher, Ajay; Meldrum, Kirstan K.; Wang, Meijing; Tsai, Ben M.; Pitcher, Jeffrey M.; Meldrum, Daniel R.

In: Cardiovascular Research, Vol. 67, No. 4, 01.09.2005, p. 594-603.

Research output: Contribution to journalArticle

Kher, Ajay ; Meldrum, Kirstan K. ; Wang, Meijing ; Tsai, Ben M. ; Pitcher, Jeffrey M. ; Meldrum, Daniel R. / Cellular and molecular mechanisms of sex differences in renal ischemia-reperfusion injury. In: Cardiovascular Research. 2005 ; Vol. 67, No. 4. pp. 594-603.
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