Cellular and physiological effects of short-chain fatty acids

Research output: Contribution to journalReview article

66 Scopus citations


Short chain fatty acids (SCFA) have multiple in vivo and in vitro effects including cell cycle arrest and induction of protein synthesis, differentiation, and apoptosis. Butyrate or derivatives have promise for treating inflammatory bowel disease and colon cancer. Genomic and proteomic analysis have generated new knowledge on function and applications for SCFA.

Original languageEnglish (US)
Pages (from-to)839-845
Number of pages7
JournalMini-Reviews in Medicinal Chemistry
Issue number8
StatePublished - Oct 2004


  • Butyrate
  • Cancer
  • Colon and fiber
  • Inflammation
  • Short chain fatty acids

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Chemistry(all)
  • Pharmacology

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