Cellular Aspects of Nerve Injury and Regeneration

Rena M. Meadows, Dale R. Sengelaub, Kathryn J. Jones

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Sensory and motor deficits resulting from peripheral nerve injury negatively impact quality of life and can require long-term rehabilitation and care. Despite the ability of nerves to robustly regenerate following peripheral nerve injury (PNI), functional recovery is often suboptimal. Surgery is required to treat patients in 50% of PNI cases, and there is no nonsurgical treatment strategy in clinical use today to treat PNI. Emerging evidence indicates that treatments affecting multiple targets and pathways have great potential. Here, we discuss data combining surgical repair with membrane fusion, electrical stimulation, and androgens to maintain appropriate channels for axons to regenerate back to their appropriate target and accelerate the regeneration process. Developing a therapy that impacts both axonal regeneration and functional recovery offers immediate translational opportunity in a clinical setting.

Original languageEnglish (US)
Title of host publicationPain, Treatment, Injury, Disease and Future Directions
PublisherElsevier
Pages433-449
Number of pages17
Volume2
ISBN (Electronic)9780128026953
ISBN (Print)9780128026533
DOIs
StatePublished - Apr 23 2015

Keywords

  • Androgens
  • Combinatorial approach
  • Electrical stimulation
  • Peripheral nerve injury
  • Surgical repair

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Meadows, R. M., Sengelaub, D. R., & Jones, K. J. (2015). Cellular Aspects of Nerve Injury and Regeneration. In Pain, Treatment, Injury, Disease and Future Directions (Vol. 2, pp. 433-449). Elsevier. https://doi.org/10.1016/B978-0-12-802653-3.00078-6