Cellular interactions in hemopoietic progenitor cell homing

A review

C. L. Hardy, J. J. Minguell, G. David Roodman, J. S. Greenberger, T. D. Allen

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Within the bone marrow microenvironment, dynamic cellular interactions are constantly occurring. These interactions involve hemopoietic stem cells, progenitor cells and maturing cells, physically interacting with other cells, some of which may function as accessory cells, and others which comprise the stromal elements; hemopoietic cells also interact with non-cellular elements, such as glycoproteins and fibrous proteins of the extracellular matrix (ECM). These interactions serve to regulate normal hemopoiesis by allowing the communication of regulatory information, migration and subsequent homing of stem cells within specific organs, and presentation of hemopoietic growth factors in a biologically relevant fashion. The goal of this review is to examine the specific cellular interactions that relate to the phenomenon of homing of intravenously transplanted stem cells to the bone marrow.

Original languageEnglish (US)
Pages (from-to)333-341
Number of pages9
JournalScanning Microscopy
Volume7
Issue number1
StatePublished - Mar 1993
Externally publishedYes

Fingerprint

homing
Stem cells
stem cells
Bone
cells
bone marrow
Glycoproteins
Accessories
interactions
accessories
Proteins
organs
Communication
communication
proteins
matrices

ASJC Scopus subject areas

  • Instrumentation

Cite this

Hardy, C. L., Minguell, J. J., Roodman, G. D., Greenberger, J. S., & Allen, T. D. (1993). Cellular interactions in hemopoietic progenitor cell homing: A review. Scanning Microscopy, 7(1), 333-341.

Cellular interactions in hemopoietic progenitor cell homing : A review. / Hardy, C. L.; Minguell, J. J.; Roodman, G. David; Greenberger, J. S.; Allen, T. D.

In: Scanning Microscopy, Vol. 7, No. 1, 03.1993, p. 333-341.

Research output: Contribution to journalArticle

Hardy, CL, Minguell, JJ, Roodman, GD, Greenberger, JS & Allen, TD 1993, 'Cellular interactions in hemopoietic progenitor cell homing: A review', Scanning Microscopy, vol. 7, no. 1, pp. 333-341.
Hardy CL, Minguell JJ, Roodman GD, Greenberger JS, Allen TD. Cellular interactions in hemopoietic progenitor cell homing: A review. Scanning Microscopy. 1993 Mar;7(1):333-341.
Hardy, C. L. ; Minguell, J. J. ; Roodman, G. David ; Greenberger, J. S. ; Allen, T. D. / Cellular interactions in hemopoietic progenitor cell homing : A review. In: Scanning Microscopy. 1993 ; Vol. 7, No. 1. pp. 333-341.
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