Cellular localization of PRL-1 and PRL-2 gene expression in normal adult human tissues

Carmen M. Dumaual, George E. Sandusky, Pamela L. Crowell, Stephen K. Randall

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Recent evidence suggests that the PRL-1 and -2 phosphatases may be multifunctional enzymes with diverse roles in a variety of tissue and cell types. Northern blotting has previously shown widespread expression of both transcripts; however, little is known about the cell type-specific expression of either gene, especially in human tissues. Therefore, we investigated expression patterns for PRL-1 and -2 genes in multiple normal, adult human tissues using in situ hybridization. Although both transcripts were ubiquitously expressed, they exhibited strikingly different patterns of expression. PRL-2 was expressed heavily in almost every tissue and cell type examined, whereas PRL-1 expression levels varied considerably both between tissue types and between individuals. Widespread expression of PRL-1 and -2 in multiple organ systems suggests an important functional role for these enzymes in normal tissue homeostasis. In addition, the variable patterns of expression for these genes may provide distinct activities in each tissue or cell type.

Original languageEnglish (US)
Pages (from-to)1401-1412
Number of pages12
JournalJournal of Histochemistry and Cytochemistry
Volume54
Issue number12
DOIs
StatePublished - Dec 1 2006

Keywords

  • Cellular localization
  • Differential expression
  • In situ hybridization
  • mRNA
  • Normal human tissues
  • PRL-1
  • PRL-2

ASJC Scopus subject areas

  • Anatomy
  • Cell Biology

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