Cellular responses to acute injury: The role of the plasma membrane in cell response to two clostridial toxins

Joseph R. Sherwin, Robert V. Considine

Research output: Contribution to journalArticle

1 Scopus citations


The plasma membrane plays an important role in the pathogenesis of acute cell injury. This brief review outlines the role of the plasma membrane in the cellular response to two clostridial toxins, the botulinum C2 toxin and the tetanus toxin. These two toxins belong to the same family of toxins as botulinum toxin type A and type F, those used clinically for the treatment of facial spasm. The actions of C2 toxin on cultured cells give rise to an acute injury characterized by a dissociation of the actin filaments of the cell cytoskeleton. While this toxin can be lethal to intact organisms, the acute cellular response need not necessarily result in cell death. In the case of tetanus toxin, the toxin appears to perturb the plasma membrane so that the function of one important cell second messenger system, protein kinase C, is altered.

Original languageEnglish (US)
Pages (from-to)65-69
Number of pages5
JournalJournal of Voice
Issue number1
StatePublished - Mar 1994



  • Actin
  • Cell death
  • Tetanus

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Speech and Hearing
  • LPN and LVN

Cite this