Cellular responses to gravity: Extracellular, intracellular and in-between

P. Todd, D. M. Klaus, L. S. Stodieck, J. D. Smith, L. A. Staehelin, M. Kacena, B. Manfredi, A. Bukhari

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Our understanding of gravitational effects (inertial effects in the vicinity of 1 × g) on cells has matured to a stage at which it is possible to define, on the basis of experimental evidence, extracellular effects on small cells and intracellular effects on eukaryotic gravisensing cells. Yet undetermined is the nature of response, if any, of those classes of cells that are not governed solely by extracellular physical events (as are prokaryotes) and are devoid of obvious mechanical devices for sensing inertial forces (such as those possessed by certain plant cells and sensory cells of animals). This "in-between" class of cells needs to be understood on the basis of the combination of intracellular and extracellular gravity-dependent processes that govern experimentally-measurable variables that are relevant to the cell's responses to modified inertial forces. The forces that certain cell types generate or respond to are therefore compared to those imposed by approximately 1 × g in the context of cytoskeletal action and symmetry-breaking pathways.

Original languageEnglish (US)
Pages (from-to)1263-1268
Number of pages6
JournalAdvances in Space Research
Volume21
Issue number8-9
DOIs
StatePublished - Jan 1 1998
Externally publishedYes

ASJC Scopus subject areas

  • Aerospace Engineering
  • Astronomy and Astrophysics
  • Geophysics
  • Atmospheric Science
  • Space and Planetary Science
  • Earth and Planetary Sciences(all)

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    Todd, P., Klaus, D. M., Stodieck, L. S., Smith, J. D., Staehelin, L. A., Kacena, M., Manfredi, B., & Bukhari, A. (1998). Cellular responses to gravity: Extracellular, intracellular and in-between. Advances in Space Research, 21(8-9), 1263-1268. https://doi.org/10.1016/S0273-1177(97)00397-9