Central nervous system infections and pregnancy

Research output: Contribution to journalArticle

Abstract

BACKGROUND- Pregnancy is associated with a state of relative immunosuppression so that the fetus can escape immunologic rejection by the mother. The immunosuppression of pregnancy increases the risk of acquiring specific infectious diseases and increases the risk that these diseases will disseminate to the central nervous system. REVIEW SUMMARY- The maternal and fetal factors that contribute to the immunosuppression of pregnancy are reviewed. There is an increased risk of central nervous system infection and mortality from coccidioidomycosis and tuberculosis during pregnancy. The impaired cell-mediated immunity involving T-lymphocytes during pregnancy increases the risk of maternal and fetal infection with Listeria monocytogenes. Malaria during pregnancy is associated with a high incidence of maternal mortality and increased rates of abortion, stillbirth, and low birth weight. The clinical presentation of each of these infectious diseases is reviewed, as well as the morbidity and mortality of the infection to the mother and the fetus and the recommended antimicrobial therapy of the infection with consideration of the risk of teratogenicity. The recent information on the reduction in the transmission of the human immunodeficiency virus from mother to infant by the administration of zidovudine during pregnancy is also included. CONCLUSION- Although there is an increased risk of central nervous system infection by certain pathogens during pregnancy, these infections can be effectively managed with delivery of a healthy infant.

Original languageEnglish
Pages (from-to)241-247
Number of pages7
JournalNeurologist
Volume3
Issue number4
StatePublished - 1997

Fingerprint

Central Nervous System Infections
Pregnancy
Mothers
Immunosuppression
Infection
Communicable Diseases
Mortality
Fetus
Coccidioidomycosis
Stillbirth
Zidovudine
Maternal Mortality
Listeria monocytogenes
Low Birth Weight Infant
Cellular Immunity
Malaria
Tuberculosis
Central Nervous System
HIV
Morbidity

Keywords

  • Infection
  • Pregnancy

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Central nervous system infections and pregnancy. / Roos, Karen.

In: Neurologist, Vol. 3, No. 4, 1997, p. 241-247.

Research output: Contribution to journalArticle

Roos, Karen. / Central nervous system infections and pregnancy. In: Neurologist. 1997 ; Vol. 3, No. 4. pp. 241-247.
@article{59902bddda3f463a9b4b9b2c7c6e3b1d,
title = "Central nervous system infections and pregnancy",
abstract = "BACKGROUND- Pregnancy is associated with a state of relative immunosuppression so that the fetus can escape immunologic rejection by the mother. The immunosuppression of pregnancy increases the risk of acquiring specific infectious diseases and increases the risk that these diseases will disseminate to the central nervous system. REVIEW SUMMARY- The maternal and fetal factors that contribute to the immunosuppression of pregnancy are reviewed. There is an increased risk of central nervous system infection and mortality from coccidioidomycosis and tuberculosis during pregnancy. The impaired cell-mediated immunity involving T-lymphocytes during pregnancy increases the risk of maternal and fetal infection with Listeria monocytogenes. Malaria during pregnancy is associated with a high incidence of maternal mortality and increased rates of abortion, stillbirth, and low birth weight. The clinical presentation of each of these infectious diseases is reviewed, as well as the morbidity and mortality of the infection to the mother and the fetus and the recommended antimicrobial therapy of the infection with consideration of the risk of teratogenicity. The recent information on the reduction in the transmission of the human immunodeficiency virus from mother to infant by the administration of zidovudine during pregnancy is also included. CONCLUSION- Although there is an increased risk of central nervous system infection by certain pathogens during pregnancy, these infections can be effectively managed with delivery of a healthy infant.",
keywords = "Infection, Pregnancy",
author = "Karen Roos",
year = "1997",
language = "English",
volume = "3",
pages = "241--247",
journal = "Neurologist",
issn = "1074-7931",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Central nervous system infections and pregnancy

AU - Roos, Karen

PY - 1997

Y1 - 1997

N2 - BACKGROUND- Pregnancy is associated with a state of relative immunosuppression so that the fetus can escape immunologic rejection by the mother. The immunosuppression of pregnancy increases the risk of acquiring specific infectious diseases and increases the risk that these diseases will disseminate to the central nervous system. REVIEW SUMMARY- The maternal and fetal factors that contribute to the immunosuppression of pregnancy are reviewed. There is an increased risk of central nervous system infection and mortality from coccidioidomycosis and tuberculosis during pregnancy. The impaired cell-mediated immunity involving T-lymphocytes during pregnancy increases the risk of maternal and fetal infection with Listeria monocytogenes. Malaria during pregnancy is associated with a high incidence of maternal mortality and increased rates of abortion, stillbirth, and low birth weight. The clinical presentation of each of these infectious diseases is reviewed, as well as the morbidity and mortality of the infection to the mother and the fetus and the recommended antimicrobial therapy of the infection with consideration of the risk of teratogenicity. The recent information on the reduction in the transmission of the human immunodeficiency virus from mother to infant by the administration of zidovudine during pregnancy is also included. CONCLUSION- Although there is an increased risk of central nervous system infection by certain pathogens during pregnancy, these infections can be effectively managed with delivery of a healthy infant.

AB - BACKGROUND- Pregnancy is associated with a state of relative immunosuppression so that the fetus can escape immunologic rejection by the mother. The immunosuppression of pregnancy increases the risk of acquiring specific infectious diseases and increases the risk that these diseases will disseminate to the central nervous system. REVIEW SUMMARY- The maternal and fetal factors that contribute to the immunosuppression of pregnancy are reviewed. There is an increased risk of central nervous system infection and mortality from coccidioidomycosis and tuberculosis during pregnancy. The impaired cell-mediated immunity involving T-lymphocytes during pregnancy increases the risk of maternal and fetal infection with Listeria monocytogenes. Malaria during pregnancy is associated with a high incidence of maternal mortality and increased rates of abortion, stillbirth, and low birth weight. The clinical presentation of each of these infectious diseases is reviewed, as well as the morbidity and mortality of the infection to the mother and the fetus and the recommended antimicrobial therapy of the infection with consideration of the risk of teratogenicity. The recent information on the reduction in the transmission of the human immunodeficiency virus from mother to infant by the administration of zidovudine during pregnancy is also included. CONCLUSION- Although there is an increased risk of central nervous system infection by certain pathogens during pregnancy, these infections can be effectively managed with delivery of a healthy infant.

KW - Infection

KW - Pregnancy

UR - http://www.scopus.com/inward/record.url?scp=3042996684&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=3042996684&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:3042996684

VL - 3

SP - 241

EP - 247

JO - Neurologist

JF - Neurologist

SN - 1074-7931

IS - 4

ER -