Central nervous system injury by therapeutic irradiation

Research output: Contribution to journalReview article

72 Scopus citations


The central nervous system toxicity of therapeutic irradiation manifests as a spectrum of clinical syndromes, ranging from transient and benign symptoms to disabling and even fatal necrosis of the brain or spinal cord. It has become clear that the brain may suffer diffuse injury, particularly in children, by doses of irradiation previously considered to be safe. In addition to directly injuring the brain or spinal cord, therapeutic irradiation can induce cerebrovascular disease and is being increasingly recognized as a cause of ''second neoplasms'' including meningiomas and gliomas.

Original languageEnglish (US)
Pages (from-to)969-988
Number of pages20
JournalNeurologic clinics
Issue number4
StatePublished - 1991
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology

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