Central nervous system injury by therapeutic irradiation

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

The central nervous system toxicity of therapeutic irradiation manifests as a spectrum of clinical syndromes, ranging from transient and benign symptoms to disabling and even fatal necrosis of the brain or spinal cord. It has become clear that the brain may suffer diffuse injury, particularly in children, by doses of irradiation previously considered to be safe. In addition to directly injuring the brain or spinal cord, therapeutic irradiation can induce cerebrovascular disease and is being increasingly recognized as a cause of ''second neoplasms'' including meningiomas and gliomas.

Original languageEnglish (US)
Pages (from-to)969-988
Number of pages20
JournalNeurologic Clinics
Volume9
Issue number4
StatePublished - 1991
Externally publishedYes

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Nervous System Trauma
Central Nervous System
Spinal Cord
Brain
Cerebrovascular Disorders
Second Primary Neoplasms
Meningioma
Glioma
Necrosis
Therapeutics
Wounds and Injuries

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Central nervous system injury by therapeutic irradiation. / Dropcho, Edward.

In: Neurologic Clinics, Vol. 9, No. 4, 1991, p. 969-988.

Research output: Contribution to journalArticle

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