Central precocious puberty: From genetics to treatment

Rebecca Schneider Aguirre, Erica A. Eugster

Research output: Contribution to journalReview article

12 Scopus citations


Central precocious puberty (CPP) results from early activation of the hypothalamic - pituitary -gonadal (HPG) axis and follows the same sequence as normal puberty. While many factors involved in pubertal initiation remain poorly understood, the kisspeptin system is known to play a key role. Currently, mutations in the kisspeptin system, MKRN3, and DLK1 have been identified in sporadic and familial cases of CPP. The diagnosis is based on physical exam findings indicating advancing puberty and on laboratory tests confirming central HPG axis activation. GnRH analogs are the mainstay of treatment and are used with the goal of height preservation. Newer extended release formulations continue to be developed. Currently there is no evidence of long-term complications associated with treatment. However, many areas remain to be explored such as targeted therapies and aspects of clinical management. Further investigation into psychological effects and additional data regarding long-term outcomes, particularly in males, is needed.

Original languageEnglish (US)
Pages (from-to)343-354
Number of pages12
JournalBest Practice and Research: Clinical Endocrinology and Metabolism
Issue number4
StatePublished - Aug 2018


  • central precocious puberty
  • etiology
  • genetics
  • outcome
  • treatment

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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