Cerebellar ataxia and central nervous system whipple disease

Brandy R. Matthews, Lyell K. Jones, Dahlia A. Saad, Allen J. Aksamit, Keith A. Josephs

Research output: Contribution to journalArticle

45 Scopus citations


Background: Whipple disease (WD) is an infectious disease, which may affect the central nervous system. Central nervous system symptoms are eventually present in as many as 43% of the cases. To our knowledge, cerebellar ataxia in WD has never been formally studied in any large series. Objective: To determine the prevalence of cerebellar ataxia in central nervous system WD. Results: Between January 1974 and December 2003, we identified 11 patients who met criteria for definite central nervous system WD, the second largest series to date. Surprisingly, while oculomasticatory myorrhythmia was recorded in only 1 patient (9%), cerebellar ataxia had been documented in 5 cases (45%). Conclusion: Our data suggest that cerebellar ataxia should be considered a more common feature of central nervous system WD.

Original languageEnglish (US)
Pages (from-to)618-620
Number of pages3
JournalArchives of Neurology
Issue number4
StatePublished - Apr 1 2005
Externally publishedYes

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

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