Cerebellar ataxia and central nervous system whipple disease

Brandy Matthews, Lyell K. Jones, Dahlia A. Saad, Allen J. Aksamit, Keith A. Josephs

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Background: Whipple disease (WD) is an infectious disease, which may affect the central nervous system. Central nervous system symptoms are eventually present in as many as 43% of the cases. To our knowledge, cerebellar ataxia in WD has never been formally studied in any large series. Objective: To determine the prevalence of cerebellar ataxia in central nervous system WD. Results: Between January 1974 and December 2003, we identified 11 patients who met criteria for definite central nervous system WD, the second largest series to date. Surprisingly, while oculomasticatory myorrhythmia was recorded in only 1 patient (9%), cerebellar ataxia had been documented in 5 cases (45%). Conclusion: Our data suggest that cerebellar ataxia should be considered a more common feature of central nervous system WD.

Original languageEnglish (US)
Pages (from-to)618-620
Number of pages3
JournalArchives of Neurology
Volume62
Issue number4
DOIs
StatePublished - Apr 2005
Externally publishedYes

Fingerprint

Whipple Disease
Cerebellar Ataxia
Central Nervous System Diseases
Central Nervous System
Communicable Diseases

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Matthews, B., Jones, L. K., Saad, D. A., Aksamit, A. J., & Josephs, K. A. (2005). Cerebellar ataxia and central nervous system whipple disease. Archives of Neurology, 62(4), 618-620. https://doi.org/10.1001/archneur.62.4.618

Cerebellar ataxia and central nervous system whipple disease. / Matthews, Brandy; Jones, Lyell K.; Saad, Dahlia A.; Aksamit, Allen J.; Josephs, Keith A.

In: Archives of Neurology, Vol. 62, No. 4, 04.2005, p. 618-620.

Research output: Contribution to journalArticle

Matthews, B, Jones, LK, Saad, DA, Aksamit, AJ & Josephs, KA 2005, 'Cerebellar ataxia and central nervous system whipple disease', Archives of Neurology, vol. 62, no. 4, pp. 618-620. https://doi.org/10.1001/archneur.62.4.618
Matthews, Brandy ; Jones, Lyell K. ; Saad, Dahlia A. ; Aksamit, Allen J. ; Josephs, Keith A. / Cerebellar ataxia and central nervous system whipple disease. In: Archives of Neurology. 2005 ; Vol. 62, No. 4. pp. 618-620.
@article{3bbe09d1561243ebba8a640f07e48137,
title = "Cerebellar ataxia and central nervous system whipple disease",
abstract = "Background: Whipple disease (WD) is an infectious disease, which may affect the central nervous system. Central nervous system symptoms are eventually present in as many as 43{\%} of the cases. To our knowledge, cerebellar ataxia in WD has never been formally studied in any large series. Objective: To determine the prevalence of cerebellar ataxia in central nervous system WD. Results: Between January 1974 and December 2003, we identified 11 patients who met criteria for definite central nervous system WD, the second largest series to date. Surprisingly, while oculomasticatory myorrhythmia was recorded in only 1 patient (9{\%}), cerebellar ataxia had been documented in 5 cases (45{\%}). Conclusion: Our data suggest that cerebellar ataxia should be considered a more common feature of central nervous system WD.",
author = "Brandy Matthews and Jones, {Lyell K.} and Saad, {Dahlia A.} and Aksamit, {Allen J.} and Josephs, {Keith A.}",
year = "2005",
month = "4",
doi = "10.1001/archneur.62.4.618",
language = "English (US)",
volume = "62",
pages = "618--620",
journal = "Archives of Neurology",
issn = "0003-9942",
publisher = "American Medical Association",
number = "4",

}

TY - JOUR

T1 - Cerebellar ataxia and central nervous system whipple disease

AU - Matthews, Brandy

AU - Jones, Lyell K.

AU - Saad, Dahlia A.

AU - Aksamit, Allen J.

AU - Josephs, Keith A.

PY - 2005/4

Y1 - 2005/4

N2 - Background: Whipple disease (WD) is an infectious disease, which may affect the central nervous system. Central nervous system symptoms are eventually present in as many as 43% of the cases. To our knowledge, cerebellar ataxia in WD has never been formally studied in any large series. Objective: To determine the prevalence of cerebellar ataxia in central nervous system WD. Results: Between January 1974 and December 2003, we identified 11 patients who met criteria for definite central nervous system WD, the second largest series to date. Surprisingly, while oculomasticatory myorrhythmia was recorded in only 1 patient (9%), cerebellar ataxia had been documented in 5 cases (45%). Conclusion: Our data suggest that cerebellar ataxia should be considered a more common feature of central nervous system WD.

AB - Background: Whipple disease (WD) is an infectious disease, which may affect the central nervous system. Central nervous system symptoms are eventually present in as many as 43% of the cases. To our knowledge, cerebellar ataxia in WD has never been formally studied in any large series. Objective: To determine the prevalence of cerebellar ataxia in central nervous system WD. Results: Between January 1974 and December 2003, we identified 11 patients who met criteria for definite central nervous system WD, the second largest series to date. Surprisingly, while oculomasticatory myorrhythmia was recorded in only 1 patient (9%), cerebellar ataxia had been documented in 5 cases (45%). Conclusion: Our data suggest that cerebellar ataxia should be considered a more common feature of central nervous system WD.

UR - http://www.scopus.com/inward/record.url?scp=16844367260&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=16844367260&partnerID=8YFLogxK

U2 - 10.1001/archneur.62.4.618

DO - 10.1001/archneur.62.4.618

M3 - Article

C2 - 15824262

AN - SCOPUS:16844367260

VL - 62

SP - 618

EP - 620

JO - Archives of Neurology

JF - Archives of Neurology

SN - 0003-9942

IS - 4

ER -