Cerebellar injury induces nos in purkinje cells and cerebellar afferent neurons

Dale Saxon, Alvin J. Beitz

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Purkinji: cells of the cerebellar cortex and neurons of most precerebellar nuclei are conspicuous by the absence of constitutive (neuronal) nitric oxide synthase (nNOS). Here we show that following mechanical, chemical or thermal injury to the cerebellar cortex there is an induction of nNOS in Purkinje cells as identified with NADPH- diaphorase (NADPH-d) histochemistry and nNOS immunocytochemistry. Induced nNOS and NADPH-d (inNOS/NADPH-d) first appeared 72 hours post-treatment and persisted in excess of 8 weeks. Precerebellar neurons throughout the brain stem also exhibited induced nNOS and NADPH-d with a similar time course. These results indicate that brain lesions can induce nNOS in local neurons and in neurons which are afferent to the leasioned area.

Original languageEnglish (US)
Pages (from-to)809-812
Number of pages4
JournalNeuroReport
Volume5
Issue number7
StatePublished - 1994
Externally publishedYes

Fingerprint

Afferent Neurons
Nitric Oxide Synthase Type I
Purkinje Cells
NADPH Dehydrogenase
Wounds and Injuries
Cerebellar Cortex
Neurons
Brain Stem
Hot Temperature
Immunohistochemistry
Brain

Keywords

  • Cerebellum
  • Inferior olive
  • Nitric oxide synthase
  • Purkinje cclls

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Cerebellar injury induces nos in purkinje cells and cerebellar afferent neurons. / Saxon, Dale; Beitz, Alvin J.

In: NeuroReport, Vol. 5, No. 7, 1994, p. 809-812.

Research output: Contribution to journalArticle

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