Cerebral aneurysms in a child with acquired immune deficiency syndrome during rapid immune reconstitution

Joshua L. Bonkowsky, John C. Christenson, G. William Nixon, Andrew T. Pavia

Research output: Contribution to journalArticle

26 Scopus citations


A 12-year-old boy with perinatally acquired human immunodeficiency virus infection and Centers for Disease Control and Prevention class C3 disease presented with acute onset of confusion and a right-sided movement disorder 5 months after beginning a new antiretroviral regimen. His CD4 count had been below 50 cells/μL for 4 years but had abruptly risen to more than 250 cells/μL. Computed tomographic and magnetic resonance imaging scans showed cerebral aneurysms and new cerebral lesions consistent with ischemic strokes. The presentation during immune reconstitution suggests that cerebral aneurysms in pediatric patients with acquired immune deficiency syndrome can result from an immune-mediated response to chronic vascular infection.

Original languageEnglish (US)
Pages (from-to)457-460
Number of pages4
JournalJournal of Child Neurology
Issue number6
StatePublished - Jun 2002


ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

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