Cerebral aneurysms in a child with acquired immune deficiency syndrome during rapid immune reconstitution

Joshua L. Bonkowsky, John Christenson, G. William Nixon, Andrew T. Pavia

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

A 12-year-old boy with perinatally acquired human immunodeficiency virus infection and Centers for Disease Control and Prevention class C3 disease presented with acute onset of confusion and a right-sided movement disorder 5 months after beginning a new antiretroviral regimen. His CD4 count had been below 50 cells/μL for 4 years but had abruptly risen to more than 250 cells/μL. Computed tomographic and magnetic resonance imaging scans showed cerebral aneurysms and new cerebral lesions consistent with ischemic strokes. The presentation during immune reconstitution suggests that cerebral aneurysms in pediatric patients with acquired immune deficiency syndrome can result from an immune-mediated response to chronic vascular infection.

Original languageEnglish (US)
Pages (from-to)457-460
Number of pages4
JournalJournal of Child Neurology
Volume17
Issue number6
StatePublished - Jun 2002
Externally publishedYes

Fingerprint

Intracranial Aneurysm
Acquired Immunodeficiency Syndrome
Movement Disorders
Virus Diseases
Centers for Disease Control and Prevention (U.S.)
CD4 Lymphocyte Count
Blood Vessels
Stroke
Magnetic Resonance Imaging
HIV
Pediatrics
Infection

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health

Cite this

Cerebral aneurysms in a child with acquired immune deficiency syndrome during rapid immune reconstitution. / Bonkowsky, Joshua L.; Christenson, John; Nixon, G. William; Pavia, Andrew T.

In: Journal of Child Neurology, Vol. 17, No. 6, 06.2002, p. 457-460.

Research output: Contribution to journalArticle

Bonkowsky, Joshua L. ; Christenson, John ; Nixon, G. William ; Pavia, Andrew T. / Cerebral aneurysms in a child with acquired immune deficiency syndrome during rapid immune reconstitution. In: Journal of Child Neurology. 2002 ; Vol. 17, No. 6. pp. 457-460.
@article{b09b61977b8a401d952e5e3a0644d5f3,
title = "Cerebral aneurysms in a child with acquired immune deficiency syndrome during rapid immune reconstitution",
abstract = "A 12-year-old boy with perinatally acquired human immunodeficiency virus infection and Centers for Disease Control and Prevention class C3 disease presented with acute onset of confusion and a right-sided movement disorder 5 months after beginning a new antiretroviral regimen. His CD4 count had been below 50 cells/μL for 4 years but had abruptly risen to more than 250 cells/μL. Computed tomographic and magnetic resonance imaging scans showed cerebral aneurysms and new cerebral lesions consistent with ischemic strokes. The presentation during immune reconstitution suggests that cerebral aneurysms in pediatric patients with acquired immune deficiency syndrome can result from an immune-mediated response to chronic vascular infection.",
author = "Bonkowsky, {Joshua L.} and John Christenson and Nixon, {G. William} and Pavia, {Andrew T.}",
year = "2002",
month = "6",
language = "English (US)",
volume = "17",
pages = "457--460",
journal = "Journal of Child Neurology",
issn = "0883-0738",
publisher = "SAGE Publications Inc.",
number = "6",

}

TY - JOUR

T1 - Cerebral aneurysms in a child with acquired immune deficiency syndrome during rapid immune reconstitution

AU - Bonkowsky, Joshua L.

AU - Christenson, John

AU - Nixon, G. William

AU - Pavia, Andrew T.

PY - 2002/6

Y1 - 2002/6

N2 - A 12-year-old boy with perinatally acquired human immunodeficiency virus infection and Centers for Disease Control and Prevention class C3 disease presented with acute onset of confusion and a right-sided movement disorder 5 months after beginning a new antiretroviral regimen. His CD4 count had been below 50 cells/μL for 4 years but had abruptly risen to more than 250 cells/μL. Computed tomographic and magnetic resonance imaging scans showed cerebral aneurysms and new cerebral lesions consistent with ischemic strokes. The presentation during immune reconstitution suggests that cerebral aneurysms in pediatric patients with acquired immune deficiency syndrome can result from an immune-mediated response to chronic vascular infection.

AB - A 12-year-old boy with perinatally acquired human immunodeficiency virus infection and Centers for Disease Control and Prevention class C3 disease presented with acute onset of confusion and a right-sided movement disorder 5 months after beginning a new antiretroviral regimen. His CD4 count had been below 50 cells/μL for 4 years but had abruptly risen to more than 250 cells/μL. Computed tomographic and magnetic resonance imaging scans showed cerebral aneurysms and new cerebral lesions consistent with ischemic strokes. The presentation during immune reconstitution suggests that cerebral aneurysms in pediatric patients with acquired immune deficiency syndrome can result from an immune-mediated response to chronic vascular infection.

UR - http://www.scopus.com/inward/record.url?scp=0036592884&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036592884&partnerID=8YFLogxK

M3 - Article

VL - 17

SP - 457

EP - 460

JO - Journal of Child Neurology

JF - Journal of Child Neurology

SN - 0883-0738

IS - 6

ER -