Cerebral arteriovenous malformation presenting with polycythemia vera: A case report and literature review

Mairaj T. Sami, Bradley N. Bohnstedt, Eyas M. Hattab, Raymond Markham, Aaron A. Cohen-Gadol

Research output: Contribution to journalArticle

Abstract

INTRODUCTION Cerebral arteriovenous malformations (AVM) usually present with headache, hemorrhage, or seizure. Erythropoietin (EPO) has demonstrated protective effects against ischemia within the CNS. PRESENTATION OF CASE The authors report a patient with a cerebral AVM and concurrent polycythemia associated with elevated serum EPO. Systemic EPO levels declined acutely after resection of the patient's AVM, and the polycythemia resolved in the following months. DISCUSSION Polycythemia secondary to a cerebral AVM, in the absence of extra-cerebral vascular lesions, has not been described in the literature. CONCLUSION The authors explore the mechanisms by which this patient's cerebral AVM could have induced EPO production within the brain, manifesting as polycythemia.

Original languageEnglish (US)
Pages (from-to)813-817
Number of pages5
JournalInternational Journal of Surgery Case Reports
Volume4
Issue number10
DOIs
StatePublished - Aug 28 2013

Keywords

  • Arteriovenous malformation
  • Erythropoietin
  • Microsurgical resection
  • Neurosurgical procedures
  • Polycythemia

ASJC Scopus subject areas

  • Surgery

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