Cerebral hypometabolism and grey matter density in MAPT intron 10 +3 mutation carriers

Kacie D. Deters, Shannon L. Risacher, Martin Farlow, Frederick Unverzagt, David Kareken, Gary Hutchins, Karmen Yoder, Jill R. Murrell, Salvatore Spina, Francine Epperson, Sujuan Gao, Andrew Saykin, Bernardino Ghetti

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Multiple systems tauopathy with presenile dementia (MSTD), a form of frontotemporal dementia with parkinsonism-17 with tau inclusions (FTDP-17T), is a neurodegenerative disorder caused by an (a) to (g) transition at position +3 of intron 10 of the microtubule associated protein tau (MAPT) gene. The mutation causes overexpression of 4 repeat (4R) tau isoforms with increased 4R/3R ratio leading to neurodegeneration. Clinically, these patients primarily present with behavioral variant FTD (bvFTD) and show disinhibition, disordered social comportment, and impaired executive function, memory, and speech. While altered glucose metabolism has been reported in subjects with sporadic bvFTD, it has yet to be investigated in an FTDP-17 sample of this size. In this study, eleven mutation carriers (5 males; mean age = 48.0 ± 6.9 years) and eight non-carriers (2 males; mean age = 43.7 ± 12.0 years) from a MSTD family were imaged using [18F]fluorodeoxyglucose (FDG) positron emission tomography (PET). Eight of the MAPT intron 10 +3 mutation carriers met diagnostic criteria for bvFTD at the time of the PET scan, while three MAPT intron 10 +3 carriers were not cognitively impaired at the time of scan. Non-carriers had no clinically-relevant cognitive impairment at the time of the PET scan. Additionally, ten mutation carriers (5 males; mean age = 48.04 ± 2.1 years) and seven non-carriers (2 males; mean age 46.1 ± 4.1 years) underwent magnetic resonance imaging (MRI) which is an expanded sample size from a previous study. Seven MAPT mutation carriers met diagnostic criteria for bvFTD at the time of the MRI scan. Images were assessed on a voxel-wise basis for the effect of mutation carrier status. SPM8 was used for preprocessing and statistical analyses. Compared to non-carriers, MAPT mutation carriers showed lower [18F]FDG uptake bilaterally in the medial temporal lobe, and the parietal and frontal cortices. Anatomical changes were predominantly seen bilaterally in the medial temporal lobe areas which substantially overlapped with the hypometabolism findings. These anatomical and metabolic changes overlap previously described patterns of neurodegeneration in MSTD patients and are consistent with the characteristics of their cognitive dysfunction. These results suggest that neuroimaging can describe the neuropathology associated with this MAPT mutation.

Original languageEnglish (US)
Pages (from-to)103-114
Number of pages12
JournalAmerican Journal of Neurodegenerative Diseases
Volume3
Issue number3
StatePublished - 2014

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Inteins
Microtubule-Associated Proteins
Frontotemporal Dementia
Mutation
Temporal Lobe
Positron-Emission Tomography
Fluorodeoxyglucose F18
Sample Size
Magnetic Resonance Imaging
Parietal Lobe
Gray Matter
Executive Function
Frontal Lobe
Neuroimaging
Neurodegenerative Diseases
Introns
Protein Isoforms
Glucose

Keywords

  • Behavioral variant frontotemporal dementia
  • Frontotemporal dementia with parkinsonism-17 with tau inclusions (FTDP-17T)
  • Magentic resonance imaging (MRI)
  • Microtubule associated protein tau (MAPT)
  • Multiple system tauopathy with presenile dementia (MSTD)
  • Neuroimaging
  • [F]fluorodeoxyglucose positron emission tomography ([F]FDG PET)

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Cerebral hypometabolism and grey matter density in MAPT intron 10 +3 mutation carriers. / Deters, Kacie D.; Risacher, Shannon L.; Farlow, Martin; Unverzagt, Frederick; Kareken, David; Hutchins, Gary; Yoder, Karmen; Murrell, Jill R.; Spina, Salvatore; Epperson, Francine; Gao, Sujuan; Saykin, Andrew; Ghetti, Bernardino.

In: American Journal of Neurodegenerative Diseases, Vol. 3, No. 3, 2014, p. 103-114.

Research output: Contribution to journalArticle

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AU - Risacher, Shannon L.

AU - Farlow, Martin

AU - Unverzagt, Frederick

AU - Kareken, David

AU - Hutchins, Gary

AU - Yoder, Karmen

AU - Murrell, Jill R.

AU - Spina, Salvatore

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KW - Microtubule associated protein tau (MAPT)

KW - Multiple system tauopathy with presenile dementia (MSTD)

KW - Neuroimaging

KW - [F]fluorodeoxyglucose positron emission tomography ([F]FDG PET)

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