Cerebral malaria in children

Chandy C. John, Richard I. Idro

Research output: Contribution to journalArticle

5 Scopus citations


Cerebral malaria is the leading cause of seizures and encephalopathy and a major cause of death in African children. Manifestations of cerebral malaria differ in children and adults. Intravenous quinine remains the drug of choice for cerebral malaria treatment, but intramuscular quinine and artemisinin derivatives are excellent alternatives. Intrarectal treatment with these drugs also appears to be efficacious. Recent studies have advanced our understanding of the anatomic and molecular pathogenesis of cerebral malaria, but ancillary treatments based on these studies have not decreased morbidity or mortality. Gross neurologic deficits caused by cerebral malaria frequently resolve over time, but cognitive sequelae may be more common than previously recognized.

Original languageEnglish (US)
Pages (from-to)53-58
Number of pages6
JournalInfections in Medicine
Issue number1
StatePublished - Jan 1 2003
Externally publishedYes


  • Cerebral malaria
  • Children
  • Plasmodium falciparum

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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  • Cite this

    John, C. C., & Idro, R. I. (2003). Cerebral malaria in children. Infections in Medicine, 20(1), 53-58.