Cerebral malaria: Mechanisms of brain injury and strategies for improved neurocognitive outcome

Richard Idro, Kevin Marsh, Chandy John, Charles R J Newton

Research output: Contribution to journalArticle

181 Citations (Scopus)

Abstract

Cerebral malaria is the most severe neurological complication of infection with Plasmodium falciparum. With >575,000 cases annually, children in sub-Saharan Africa are the most affected. Surviving patients have an increased risk of neurological and cognitive deficits, behavioral difficulties, and epilepsy making cerebral malaria a leading cause of childhood neurodisability in the region. The pathogenesis of neurocognitive sequelae is poorly understood: coma develops through multiple mechanisms and there may be several mechanisms of brain injury. It is unclear how an intravascular parasite causes such brain injury. Understanding these mechanisms is important to develop appropriate neuroprotective interventions. This article examines possible mechanisms of brain injury in cerebral malaria, relating this to the pathogenesis of the disease, and explores prospects for improved neurocognitive outcome.

Original languageEnglish (US)
Pages (from-to)267-274
Number of pages8
JournalPediatric Research
Volume68
Issue number4
DOIs
StatePublished - Oct 2010
Externally publishedYes

Fingerprint

Cerebral Malaria
Brain Injuries
Africa South of the Sahara
Plasmodium falciparum
Coma
Epilepsy
Parasites
Infection

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Cerebral malaria : Mechanisms of brain injury and strategies for improved neurocognitive outcome. / Idro, Richard; Marsh, Kevin; John, Chandy; Newton, Charles R J.

In: Pediatric Research, Vol. 68, No. 4, 10.2010, p. 267-274.

Research output: Contribution to journalArticle

Idro, Richard ; Marsh, Kevin ; John, Chandy ; Newton, Charles R J. / Cerebral malaria : Mechanisms of brain injury and strategies for improved neurocognitive outcome. In: Pediatric Research. 2010 ; Vol. 68, No. 4. pp. 267-274.
@article{53593d3e11d94724a8232a0677165248,
title = "Cerebral malaria: Mechanisms of brain injury and strategies for improved neurocognitive outcome",
abstract = "Cerebral malaria is the most severe neurological complication of infection with Plasmodium falciparum. With >575,000 cases annually, children in sub-Saharan Africa are the most affected. Surviving patients have an increased risk of neurological and cognitive deficits, behavioral difficulties, and epilepsy making cerebral malaria a leading cause of childhood neurodisability in the region. The pathogenesis of neurocognitive sequelae is poorly understood: coma develops through multiple mechanisms and there may be several mechanisms of brain injury. It is unclear how an intravascular parasite causes such brain injury. Understanding these mechanisms is important to develop appropriate neuroprotective interventions. This article examines possible mechanisms of brain injury in cerebral malaria, relating this to the pathogenesis of the disease, and explores prospects for improved neurocognitive outcome.",
author = "Richard Idro and Kevin Marsh and Chandy John and Newton, {Charles R J}",
year = "2010",
month = "10",
doi = "10.1203/PDR.0b013e3181eee738",
language = "English (US)",
volume = "68",
pages = "267--274",
journal = "Pediatric Research",
issn = "0031-3998",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Cerebral malaria

T2 - Mechanisms of brain injury and strategies for improved neurocognitive outcome

AU - Idro, Richard

AU - Marsh, Kevin

AU - John, Chandy

AU - Newton, Charles R J

PY - 2010/10

Y1 - 2010/10

N2 - Cerebral malaria is the most severe neurological complication of infection with Plasmodium falciparum. With >575,000 cases annually, children in sub-Saharan Africa are the most affected. Surviving patients have an increased risk of neurological and cognitive deficits, behavioral difficulties, and epilepsy making cerebral malaria a leading cause of childhood neurodisability in the region. The pathogenesis of neurocognitive sequelae is poorly understood: coma develops through multiple mechanisms and there may be several mechanisms of brain injury. It is unclear how an intravascular parasite causes such brain injury. Understanding these mechanisms is important to develop appropriate neuroprotective interventions. This article examines possible mechanisms of brain injury in cerebral malaria, relating this to the pathogenesis of the disease, and explores prospects for improved neurocognitive outcome.

AB - Cerebral malaria is the most severe neurological complication of infection with Plasmodium falciparum. With >575,000 cases annually, children in sub-Saharan Africa are the most affected. Surviving patients have an increased risk of neurological and cognitive deficits, behavioral difficulties, and epilepsy making cerebral malaria a leading cause of childhood neurodisability in the region. The pathogenesis of neurocognitive sequelae is poorly understood: coma develops through multiple mechanisms and there may be several mechanisms of brain injury. It is unclear how an intravascular parasite causes such brain injury. Understanding these mechanisms is important to develop appropriate neuroprotective interventions. This article examines possible mechanisms of brain injury in cerebral malaria, relating this to the pathogenesis of the disease, and explores prospects for improved neurocognitive outcome.

UR - http://www.scopus.com/inward/record.url?scp=77957288323&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77957288323&partnerID=8YFLogxK

U2 - 10.1203/PDR.0b013e3181eee738

DO - 10.1203/PDR.0b013e3181eee738

M3 - Article

C2 - 20606600

AN - SCOPUS:77957288323

VL - 68

SP - 267

EP - 274

JO - Pediatric Research

JF - Pediatric Research

SN - 0031-3998

IS - 4

ER -