Cerebral metabolites in patients with acute and subacute strokes: Concentrations determined by quantitative proton MR spectroscopy

Vincent Mathews, P. B. Barker, S. J. Blackband, J. C. Chatham, R. N. Bryan

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Abstract

OBJECTIVE. The purpose of this study was to determine the feasibility of measuring concentrations of cerebral metabolites in acute and subacute stroke patients using single-voxel localized proton MR spectroscopy and to compare these concentrations to those in contralateral brain regions and in normal healthy volunteers. SUBJECTS AND METHODS. Single-voxel proton MR spectroscopy and MR imaging were performed in 14 stroke patients, at times ranging from 2 hr to 10 days following the onset of symptoms. Signals from choline, creatine, N-acetyl-L-aspartate (NAA), and lactate were quantified in the infarcted region (n = 14) and in the hemisphere contralateral to the stroke (n = 8) and compared with data obtained from a group of 10 control subjects. RESULTS. Infarcts were characterized by significantly increased lactate (12 of 14 patients; 7.5 ± 8.9 μmol/g wet weight, mean ± SD) and significantly decreased NAA (12 of 14 patients; 5.5 ± 3.2 μmol/g wet weight), compared with contralateral brain regions and control data in healthy volunteers. Significant reductions in choline, creatine, and NAA were also found in contralateral brain regions compared with the control patients. CONCLUSION. Quantitative single-voxel proton spectroscopy is feasible for use in clinical studies of acute stroke. Ratio measurements or comparison with contralateral metabolites may be misleading because all metabolites may change during infarction, and contralateral metabolite levels may also be different from normal subjects.

Original languageEnglish (US)
Pages (from-to)633-638
Number of pages6
JournalAmerican Journal of Roentgenology
Volume165
Issue number3
StatePublished - 1995
Externally publishedYes

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Protons
Magnetic Resonance Spectroscopy
Stroke
Healthy Volunteers
Creatine
Choline
Lactic Acid
Brain
Weights and Measures
Infarction
Spectrum Analysis
Control Groups
N-acetylaspartate

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Cerebral metabolites in patients with acute and subacute strokes : Concentrations determined by quantitative proton MR spectroscopy. / Mathews, Vincent; Barker, P. B.; Blackband, S. J.; Chatham, J. C.; Bryan, R. N.

In: American Journal of Roentgenology, Vol. 165, No. 3, 1995, p. 633-638.

Research output: Contribution to journalArticle

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AU - Barker, P. B.

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AU - Chatham, J. C.

AU - Bryan, R. N.

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