Cerebral palsy after perinatal arteril ischemic stroke

Meredith R. Golomb, Bhuwan P. Garg, Chandan Saha, Faouzi Azzouz, Linda S. Williams

Research output: Contribution to journalArticle

59 Scopus citations

Abstract

The frequency of cerebral palsy, degree of disability, and predictors of disability were assessed in children in a perinatal arterial stroke database. Risk factors were assessed at the univariate level using the Pearson χ2 and Fisher exact test and at the multivariate level using logistic regression analysis. Seventy-six of 111 children with perinatal stroke (68%) had cerebral palsy, most commonly hemiplegic (66/76; 87%). Multivariate analysis of the entire cohort showed both delayed presentation (OR,9.96; 95% CI, 3.10-32.02) and male sex (OR, 2.55; 95% CI, 1.03-6.32) were associated with cerebral palsy. In subgroup multivariate analyses: in children with neonatal presentation, bilateral infarcts were associated with triplegia or quadriplegia (OR, 5.33; 95% CI, 1.28-22.27); in children with unilateral middle cerebral artery infarcts, delayed presentation (OR, 10.60; 95% CI, 2.28-72.92) and large-branch infarction (OR, 8.78; 95% CI, 2.18-43.67) were associated with cerebral palsy. These data will aid physicians in planning long-term rehabilitative care for children with perinatal stroke.

Original languageEnglish (US)
Pages (from-to)279-286
Number of pages8
JournalJournal of child neurology
Volume23
Issue number3
DOIs
StatePublished - Mar 1 2008

Keywords

  • Arterial ischemic stroke
  • Cerebral palsy
  • Outcomes
  • Perinatal

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health

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