Cerebral white matter disease in late-onset paranoid psychosis

John C S Breitner, Mustafa M. Husain, Gary S. Figiel, K. Ranga R Krishman, Orest Boyko

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

We examined magnetic resonance (MR) scans of the heads of 8 patients with late onset psychosis and 8 aged controls. Although some patients had mild cognitive impairment, none had depression or a history or examination suggesting focal brain disease. Thus, all patients met DSM-III-R criteria for late-onset schizophrenia All 8 patients showed significant leukoencephalopathy or vascular pathology on MR imaging, and temporoparietal and occipital lesions were especially prominent. Little such pathology was evident on control scans. We suggest that focal brain disease of vascular origin may be associated with late-onset psychosis, and that MR scanning of such cases may provide important clues to pathologenesis.

Original languageEnglish (US)
Pages (from-to)266-274
Number of pages9
JournalBiological Psychiatry
Volume28
Issue number3
StatePublished - Aug 1 1990
Externally publishedYes

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Paranoid Disorders
Leukoencephalopathies
Brain Diseases
Psychotic Disorders
Blood Vessels
Magnetic Resonance Spectroscopy
Pathology
Diagnostic and Statistical Manual of Mental Disorders
Schizophrenia
History
Head
Magnetic Resonance Imaging
Depression

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Breitner, J. C. S., Husain, M. M., Figiel, G. S., Krishman, K. R. R., & Boyko, O. (1990). Cerebral white matter disease in late-onset paranoid psychosis. Biological Psychiatry, 28(3), 266-274.

Cerebral white matter disease in late-onset paranoid psychosis. / Breitner, John C S; Husain, Mustafa M.; Figiel, Gary S.; Krishman, K. Ranga R; Boyko, Orest.

In: Biological Psychiatry, Vol. 28, No. 3, 01.08.1990, p. 266-274.

Research output: Contribution to journalArticle

Breitner, JCS, Husain, MM, Figiel, GS, Krishman, KRR & Boyko, O 1990, 'Cerebral white matter disease in late-onset paranoid psychosis', Biological Psychiatry, vol. 28, no. 3, pp. 266-274.
Breitner JCS, Husain MM, Figiel GS, Krishman KRR, Boyko O. Cerebral white matter disease in late-onset paranoid psychosis. Biological Psychiatry. 1990 Aug 1;28(3):266-274.
Breitner, John C S ; Husain, Mustafa M. ; Figiel, Gary S. ; Krishman, K. Ranga R ; Boyko, Orest. / Cerebral white matter disease in late-onset paranoid psychosis. In: Biological Psychiatry. 1990 ; Vol. 28, No. 3. pp. 266-274.
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