Cerebrospinal Fluid and Plasma Monoamine Metabolites and Their Relation to Psychosis: Implications for Regional Brain Dysfunction in Schizophrenia

David Pickar, Alan Breier, John K. Hsiao, Allen R. Doran, Owen M. Wolkowitz, Carlos N. Pato, P. Eric Konicki, William Z. Potter

Research output: Contribution to journalArticle

80 Scopus citations

Abstract

The relationship between central (cerebrospinal fluid [CSF]) and peripheral (plasma) monoaminergic metabolites and psychotic symptoms was examined in 22 drug-free schizophrenic inpatients. The CSF homovanillic acid levels did not differ significantly between patients and normal controls (n = 33). The CSF homovanillic acid levels, however, were negatively correlated with ratings of psychosis and positive symptoms, and the CSF homovanillic acid and 5-hydroxyindoleacetic acid levels correlated negatively with individual deficit symptoms. Stepwise and hierarchical multiple-regression analysis revealed that among monoaminergic measures, only the CSF and plasma homovanillic acid levels contributed significantly to the total Brief Psychiatric Rating Scale and positive symptom variance with negative and positive partial correlations, respectively. Levels of CSF 3-methoxy-4-hydroxyphenylglycol, but not of CSF norepinephrine, were significantly elevated in the schizophrenic patients compared with controls, and plasma 3-methoxy-4-hydroxyphenylglycol levels were positively correlated with negative symptoms. We discuss the potential implications of these findings for a model of dopaminergic dysfunction in schizophrenia involving distinct cortical and subcortical contributions.

Original languageEnglish (US)
Pages (from-to)641-648
Number of pages8
JournalArchives of general psychiatry
Volume47
Issue number7
DOIs
StatePublished - Jul 1990
Externally publishedYes

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health

Fingerprint Dive into the research topics of 'Cerebrospinal Fluid and Plasma Monoamine Metabolites and Their Relation to Psychosis: Implications for Regional Brain Dysfunction in Schizophrenia'. Together they form a unique fingerprint.

  • Cite this