Cerebrospinal fluid and plasma monoamines and their metabolites in euthymic bipolar patients

Wade H. Berrettini, John I. Nurnberger, Mika Scheinin, Timo Seppala, Markku Linnoila, William Narrow, Susan Simmons-Alling, Elliot S. Gershon

Research output: Contribution to journalArticle

47 Scopus citations

Abstract

In a search for trait markers in manic-depressive illness, we studied cerebrospinal fluid (CSF) and plasma monoamines and their metabolites in 25 lithium-treated euthymic bipolar patients (12 of whom provided unmedicated samples) and 30 normal volunteers. No group differences were found. Lithium treatment showed a trend to increase CSF hydroxy-indoleacetic acid (HIAA) (p = 0.05). Dopaminergic and serotonergic metabolites were highly correlated in the CSF of all three groups. We found no evidence of a trait marker for manic-depressive illness among CSF monoamines and their metabolites.

Original languageEnglish (US)
Pages (from-to)257-269
Number of pages13
JournalBiological psychiatry
Volume20
Issue number3
DOIs
StatePublished - Mar 1985
Externally publishedYes

ASJC Scopus subject areas

  • Biological Psychiatry

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    Berrettini, W. H., Nurnberger, J. I., Scheinin, M., Seppala, T., Linnoila, M., Narrow, W., Simmons-Alling, S., & Gershon, E. S. (1985). Cerebrospinal fluid and plasma monoamines and their metabolites in euthymic bipolar patients. Biological psychiatry, 20(3), 257-269. https://doi.org/10.1016/0006-3223(85)90055-1