Cerebrospinal fluid and plasma monoamines and their metabolites in euthymic bipolar patients

Wade H. Berrettini, John Nurnberger, Mika Scheinin, Timo Seppala, Markku Linnoila, William Narrow, Susan Simmons-Alling, Elliot S. Gershon

Research output: Contribution to journalArticle

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Abstract

In a search for trait markers in manic-depressive illness, we studied cerebrospinal fluid (CSF) and plasma monoamines and their metabolites in 25 lithium-treated euthymic bipolar patients (12 of whom provided unmedicated samples) and 30 normal volunteers. No group differences were found. Lithium treatment showed a trend to increase CSF hydroxy-indoleacetic acid (HIAA) (p = 0.05). Dopaminergic and serotonergic metabolites were highly correlated in the CSF of all three groups. We found no evidence of a trait marker for manic-depressive illness among CSF monoamines and their metabolites.

Original languageEnglish (US)
Pages (from-to)257-269
Number of pages13
JournalBiological Psychiatry
Volume20
Issue number3
DOIs
StatePublished - 1985
Externally publishedYes

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Cerebrospinal Fluid
Lithium
Healthy Volunteers
Major Affective Disorder 2
Therapeutics

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Berrettini, W. H., Nurnberger, J., Scheinin, M., Seppala, T., Linnoila, M., Narrow, W., ... Gershon, E. S. (1985). Cerebrospinal fluid and plasma monoamines and their metabolites in euthymic bipolar patients. Biological Psychiatry, 20(3), 257-269. https://doi.org/10.1016/0006-3223(85)90055-1

Cerebrospinal fluid and plasma monoamines and their metabolites in euthymic bipolar patients. / Berrettini, Wade H.; Nurnberger, John; Scheinin, Mika; Seppala, Timo; Linnoila, Markku; Narrow, William; Simmons-Alling, Susan; Gershon, Elliot S.

In: Biological Psychiatry, Vol. 20, No. 3, 1985, p. 257-269.

Research output: Contribution to journalArticle

Berrettini, WH, Nurnberger, J, Scheinin, M, Seppala, T, Linnoila, M, Narrow, W, Simmons-Alling, S & Gershon, ES 1985, 'Cerebrospinal fluid and plasma monoamines and their metabolites in euthymic bipolar patients', Biological Psychiatry, vol. 20, no. 3, pp. 257-269. https://doi.org/10.1016/0006-3223(85)90055-1
Berrettini, Wade H. ; Nurnberger, John ; Scheinin, Mika ; Seppala, Timo ; Linnoila, Markku ; Narrow, William ; Simmons-Alling, Susan ; Gershon, Elliot S. / Cerebrospinal fluid and plasma monoamines and their metabolites in euthymic bipolar patients. In: Biological Psychiatry. 1985 ; Vol. 20, No. 3. pp. 257-269.
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