Cerebrospinal fluid cytokine levels and cognitive impairment in cerebral malaria

Chandy John, Angela Panoskaltsis-Mortari, Robert O. Opoka, Gregory S. Park, Paul J. Orchard, Anne M. Jurek, Richard Idro, Justus Byarugaba, Michael J. Boivin

Research output: Contribution to journalArticle

101 Citations (Scopus)

Abstract

Cerebrospinal fluid (CSF) and serum levels of 12 cytokines or chemokines important in central nervous system (CNS) infections were measured in 76 Ugandan children with cerebral malaria (CM) and 8 control children. As compared with control children, children with cerebral malaria had higher cerebrospinal fluid levels of interleukin (IL)-6, CXCL-8/IL-8, granulocyte-colony stimulating factor (G-CSF), tumor necrosis factor-α (TNF-α), and IL-1 receptor antagonist. There was no correlation between cerebrospinal and serum cytokine levels for any cytokine except G-CSF. Elevated cerebrospinal fluid but not serum TNF-α levels on admission were associated with an increased risk of neurologic deficits 3 months later (odds ratio 1.55, 95% CI: 1.10, 2.18, P = 0.01) and correlated negatively with age-adjusted scores for attention (Spearman rho, -0.34, P = 0.04) and working memory (Spearman rho, -0.32, P = 0.06) 6 months later. In children with cerebral malaria, central nervous system TNF-α production is associated with subsequent neurologic and cognitive morbidity.

Original languageEnglish (US)
Pages (from-to)198-205
Number of pages8
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume78
Issue number2
StatePublished - Feb 2008
Externally publishedYes

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Cerebral Malaria
Cerebrospinal Fluid
Cytokines
Tumor Necrosis Factor-alpha
Granulocyte Colony-Stimulating Factor
Serum
Central Nervous System Infections
Interleukin-1 Receptors
Neurologic Manifestations
Interleukin-8
Short-Term Memory
Chemokines
Nervous System
Interleukin-6
Central Nervous System
Odds Ratio
Cognitive Dysfunction
Morbidity

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Cite this

John, C., Panoskaltsis-Mortari, A., Opoka, R. O., Park, G. S., Orchard, P. J., Jurek, A. M., ... Boivin, M. J. (2008). Cerebrospinal fluid cytokine levels and cognitive impairment in cerebral malaria. American Journal of Tropical Medicine and Hygiene, 78(2), 198-205.

Cerebrospinal fluid cytokine levels and cognitive impairment in cerebral malaria. / John, Chandy; Panoskaltsis-Mortari, Angela; Opoka, Robert O.; Park, Gregory S.; Orchard, Paul J.; Jurek, Anne M.; Idro, Richard; Byarugaba, Justus; Boivin, Michael J.

In: American Journal of Tropical Medicine and Hygiene, Vol. 78, No. 2, 02.2008, p. 198-205.

Research output: Contribution to journalArticle

John, C, Panoskaltsis-Mortari, A, Opoka, RO, Park, GS, Orchard, PJ, Jurek, AM, Idro, R, Byarugaba, J & Boivin, MJ 2008, 'Cerebrospinal fluid cytokine levels and cognitive impairment in cerebral malaria', American Journal of Tropical Medicine and Hygiene, vol. 78, no. 2, pp. 198-205.
John C, Panoskaltsis-Mortari A, Opoka RO, Park GS, Orchard PJ, Jurek AM et al. Cerebrospinal fluid cytokine levels and cognitive impairment in cerebral malaria. American Journal of Tropical Medicine and Hygiene. 2008 Feb;78(2):198-205.
John, Chandy ; Panoskaltsis-Mortari, Angela ; Opoka, Robert O. ; Park, Gregory S. ; Orchard, Paul J. ; Jurek, Anne M. ; Idro, Richard ; Byarugaba, Justus ; Boivin, Michael J. / Cerebrospinal fluid cytokine levels and cognitive impairment in cerebral malaria. In: American Journal of Tropical Medicine and Hygiene. 2008 ; Vol. 78, No. 2. pp. 198-205.
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