Cerebrospinal Fluid Histoplasma Antibodies in Central Nervous System Histoplasmosis

Joseph Wheat, Morris French, Byron Batteiger, Richard Kohler

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

We have evaluated the Histoplasma antibody response in the cerebrospinal fluid (CSF) in nine patients with central nervous system histoplasmosis and 98 controls. While the CSF Histoplasma antibody response identified eight of the nine patients, CSF cultures were positive in only two. Of controls with histoplasmosis but without meningitis (13 patients), or without histoplasmosis (85 patients), elevated CSF antibodies were detected by complement fixation in seven, by IgG radioimmunoassay in 17, and by IgM radioimmunoassay in five. Measurement of the CSF Histoplasma antibody response appears useful for identifying meningitis in patients with histoplasmosis, although cross-reactions occur in half of patients with other forms of chronic fungal meningitis. Patients with these other infections can usually be identified by tests for CSF Coccidioides antibodies, or cryptococcal antigens.

Original languageEnglish
Pages (from-to)1237-1240
Number of pages4
JournalArchives of Internal Medicine
Volume145
Issue number7
DOIs
StatePublished - 1985

Fingerprint

Histoplasma
Histoplasmosis
Cerebrospinal Fluid
Central Nervous System
Antibodies
Antibody Formation
Meningitis
Radioimmunoassay
Fungal Meningitis
Coccidioides
Cross Reactions
Immunoglobulin M
Immunoglobulin G
Antigens
Infection

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Cerebrospinal Fluid Histoplasma Antibodies in Central Nervous System Histoplasmosis. / Wheat, Joseph; French, Morris; Batteiger, Byron; Kohler, Richard.

In: Archives of Internal Medicine, Vol. 145, No. 7, 1985, p. 1237-1240.

Research output: Contribution to journalArticle

Wheat, Joseph ; French, Morris ; Batteiger, Byron ; Kohler, Richard. / Cerebrospinal Fluid Histoplasma Antibodies in Central Nervous System Histoplasmosis. In: Archives of Internal Medicine. 1985 ; Vol. 145, No. 7. pp. 1237-1240.
@article{85798a56f7f04e9d92e5e1f8265e667e,
title = "Cerebrospinal Fluid Histoplasma Antibodies in Central Nervous System Histoplasmosis",
abstract = "We have evaluated the Histoplasma antibody response in the cerebrospinal fluid (CSF) in nine patients with central nervous system histoplasmosis and 98 controls. While the CSF Histoplasma antibody response identified eight of the nine patients, CSF cultures were positive in only two. Of controls with histoplasmosis but without meningitis (13 patients), or without histoplasmosis (85 patients), elevated CSF antibodies were detected by complement fixation in seven, by IgG radioimmunoassay in 17, and by IgM radioimmunoassay in five. Measurement of the CSF Histoplasma antibody response appears useful for identifying meningitis in patients with histoplasmosis, although cross-reactions occur in half of patients with other forms of chronic fungal meningitis. Patients with these other infections can usually be identified by tests for CSF Coccidioides antibodies, or cryptococcal antigens.",
author = "Joseph Wheat and Morris French and Byron Batteiger and Richard Kohler",
year = "1985",
doi = "10.1001/archinte.1985.00360070115018",
language = "English",
volume = "145",
pages = "1237--1240",
journal = "JAMA Internal Medicine",
issn = "2168-6106",
publisher = "American Medical Association",
number = "7",

}

TY - JOUR

T1 - Cerebrospinal Fluid Histoplasma Antibodies in Central Nervous System Histoplasmosis

AU - Wheat, Joseph

AU - French, Morris

AU - Batteiger, Byron

AU - Kohler, Richard

PY - 1985

Y1 - 1985

N2 - We have evaluated the Histoplasma antibody response in the cerebrospinal fluid (CSF) in nine patients with central nervous system histoplasmosis and 98 controls. While the CSF Histoplasma antibody response identified eight of the nine patients, CSF cultures were positive in only two. Of controls with histoplasmosis but without meningitis (13 patients), or without histoplasmosis (85 patients), elevated CSF antibodies were detected by complement fixation in seven, by IgG radioimmunoassay in 17, and by IgM radioimmunoassay in five. Measurement of the CSF Histoplasma antibody response appears useful for identifying meningitis in patients with histoplasmosis, although cross-reactions occur in half of patients with other forms of chronic fungal meningitis. Patients with these other infections can usually be identified by tests for CSF Coccidioides antibodies, or cryptococcal antigens.

AB - We have evaluated the Histoplasma antibody response in the cerebrospinal fluid (CSF) in nine patients with central nervous system histoplasmosis and 98 controls. While the CSF Histoplasma antibody response identified eight of the nine patients, CSF cultures were positive in only two. Of controls with histoplasmosis but without meningitis (13 patients), or without histoplasmosis (85 patients), elevated CSF antibodies were detected by complement fixation in seven, by IgG radioimmunoassay in 17, and by IgM radioimmunoassay in five. Measurement of the CSF Histoplasma antibody response appears useful for identifying meningitis in patients with histoplasmosis, although cross-reactions occur in half of patients with other forms of chronic fungal meningitis. Patients with these other infections can usually be identified by tests for CSF Coccidioides antibodies, or cryptococcal antigens.

UR - http://www.scopus.com/inward/record.url?scp=0021931395&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021931395&partnerID=8YFLogxK

U2 - 10.1001/archinte.1985.00360070115018

DO - 10.1001/archinte.1985.00360070115018

M3 - Article

C2 - 4015272

AN - SCOPUS:0021931395

VL - 145

SP - 1237

EP - 1240

JO - JAMA Internal Medicine

JF - JAMA Internal Medicine

SN - 2168-6106

IS - 7

ER -