Cerebrospinal fluid levels of amyloid β-protein precursor are low in gerstmann-sträussler-scheinker disease, Indiana kindred

Martin Farlow, Bernardino Ghetti, Stephen Dlouhy, G. Giaccone, O. Bugiani, F. Tagliavini, S. Wagner

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We studied levels of amyloid β-protein precursor (β PP) in CSF from four patients affected with Gerstmann-Sträussler-Scheinker disease and one asymptomatic gene-carrier from an Indiana kindred. Levels of βPP were decreased in all affected patients with the lowest levels occurring in the clinically most severely affected patients. Correlation of neuropathology with CSF data in three patients suggested that low βPP in CSF may be associated with βPP accumulation in neurites surrounding cortical and cerebellar amyloid deposits.

Original languageEnglish
Pages (from-to)1508-1510
Number of pages3
JournalNeurology
Volume44
Issue number8
StatePublished - 1994

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Amyloid beta-Protein Precursor
Protein Precursors
Cerebrospinal Fluid
Asymptomatic Diseases
Amyloid Plaques
Neurites
Precursor
Protein
Genes

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Cerebrospinal fluid levels of amyloid β-protein precursor are low in gerstmann-sträussler-scheinker disease, Indiana kindred. / Farlow, Martin; Ghetti, Bernardino; Dlouhy, Stephen; Giaccone, G.; Bugiani, O.; Tagliavini, F.; Wagner, S.

In: Neurology, Vol. 44, No. 8, 1994, p. 1508-1510.

Research output: Contribution to journalArticle

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AU - Wagner, S.

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