Cerebrospinal fluid levels of amyloid β-protein precursor are low in gerstmann-sträussler-scheinker disease, Indiana kindred

Martin R. Farlow, B. Ghetti, S. Dlouhy, G. Giaccone, O. Bugiani, F. Tagliavini, S. Wagner

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

We studied levels of amyloid β-protein precursor (β PP) in CSF from four patients affected with Gerstmann-Sträussler-Scheinker disease and one asymptomatic gene-carrier from an Indiana kindred. Levels of βPP were decreased in all affected patients with the lowest levels occurring in the clinically most severely affected patients. Correlation of neuropathology with CSF data in three patients suggested that low βPP in CSF may be associated with βPP accumulation in neurites surrounding cortical and cerebellar amyloid deposits.

Original languageEnglish (US)
Pages (from-to)1508-1510
Number of pages3
JournalNeurology
Volume44
Issue number8
StatePublished - Aug 1994

ASJC Scopus subject areas

  • Clinical Neurology

Fingerprint Dive into the research topics of 'Cerebrospinal fluid levels of amyloid β-protein precursor are low in gerstmann-sträussler-scheinker disease, Indiana kindred'. Together they form a unique fingerprint.

  • Cite this