Cerebrospinal fluid pressure and glaucoma

Regulation of trans-lamina cribrosa pressure

Brian Marek, Alon Harris, Priyanka Kanakamedala, Eric Lee, Annahita Amireskandari, Lucia Carichino, Giovanna Guidoboni, Leslie Abrams Tobe, Brent Siesky

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Increased trans-lamina cribrosa pressure difference (TLCPD), the difference of intraocular pressure (IOP) and orbital cerebrospinal fluid pressure (CSF-P), has been investigated as a possible risk factor in glaucoma pathogenesis. In fact, lower CSF-P in the setting of normal IOP has been implicated as a potential risk factor for normal tension glaucoma. Increased TLCPD has been associated with decreased neuroretinal rim area and increased visual field defects. Furthermore, dysregulation of systemic blood pressure has been associated with changes in IOP. Recent studies have also suggested that increased body mass index (BMI) is associated with decreased prevalence of glaucoma, which may be due to an increased CSF-P with increased BMI found in many studies. Given the interaction of various pressures, their role in glaucoma pathophysiology has come under investigation and warrants further study in order to better understand the aetiology and progression of glaucoma.

Original languageEnglish
Pages (from-to)721-725
Number of pages5
JournalBritish Journal of Ophthalmology
Volume98
Issue number6
DOIs
StatePublished - 2014

Fingerprint

Cerebrospinal Fluid Pressure
Glaucoma
Intraocular Pressure
Pressure
Body Mass Index
Low Tension Glaucoma
Visual Fields
Blood Pressure

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Cerebrospinal fluid pressure and glaucoma : Regulation of trans-lamina cribrosa pressure. / Marek, Brian; Harris, Alon; Kanakamedala, Priyanka; Lee, Eric; Amireskandari, Annahita; Carichino, Lucia; Guidoboni, Giovanna; Tobe, Leslie Abrams; Siesky, Brent.

In: British Journal of Ophthalmology, Vol. 98, No. 6, 2014, p. 721-725.

Research output: Contribution to journalArticle

Marek, B, Harris, A, Kanakamedala, P, Lee, E, Amireskandari, A, Carichino, L, Guidoboni, G, Tobe, LA & Siesky, B 2014, 'Cerebrospinal fluid pressure and glaucoma: Regulation of trans-lamina cribrosa pressure', British Journal of Ophthalmology, vol. 98, no. 6, pp. 721-725. https://doi.org/10.1136/bjophthalmol-2013-303884
Marek, Brian ; Harris, Alon ; Kanakamedala, Priyanka ; Lee, Eric ; Amireskandari, Annahita ; Carichino, Lucia ; Guidoboni, Giovanna ; Tobe, Leslie Abrams ; Siesky, Brent. / Cerebrospinal fluid pressure and glaucoma : Regulation of trans-lamina cribrosa pressure. In: British Journal of Ophthalmology. 2014 ; Vol. 98, No. 6. pp. 721-725.
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