Cerebrospinal fluid pressure and glaucoma: Regulation of trans-lamina cribrosa pressure

Brian Marek, Alon Harris, Priyanka Kanakamedala, Eric Lee, Annahita Amireskandari, Lucia Carichino, Giovanna Guidoboni, Leslie Abrams Tobe, Brent Siesky

Research output: Contribution to journalReview article

24 Scopus citations


Increased trans-lamina cribrosa pressure difference (TLCPD), the difference of intraocular pressure (IOP) and orbital cerebrospinal fluid pressure (CSF-P), has been investigated as a possible risk factor in glaucoma pathogenesis. In fact, lower CSF-P in the setting of normal IOP has been implicated as a potential risk factor for normal tension glaucoma. Increased TLCPD has been associated with decreased neuroretinal rim area and increased visual field defects. Furthermore, dysregulation of systemic blood pressure has been associated with changes in IOP. Recent studies have also suggested that increased body mass index (BMI) is associated with decreased prevalence of glaucoma, which may be due to an increased CSF-P with increased BMI found in many studies. Given the interaction of various pressures, their role in glaucoma pathophysiology has come under investigation and warrants further study in order to better understand the aetiology and progression of glaucoma.

Original languageEnglish (US)
Pages (from-to)721-725
Number of pages5
JournalBritish Journal of Ophthalmology
Issue number6
StatePublished - Jun 2014

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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